IMPLANTABLE NEAR IR GLUCOSE SENSOR

植入式近红外血糖传感器

• 批准号: 6177391
• 负责人: KATHERINE D. CROTHALL
• 金额: $ 20.47万
• 依托单位: ANIMAS CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6177391
• 关键词: biomedical equipment development; biosensor device; blood glucose; clinical research; dogs; human subject; hyperglycemia; hypoglycemia; implant; infrared radiation; insulin dependent diabetes mellitus; medical implant science

The goals of the proposal are the development and commercialization of a long-term implantable infrared glucose sensor for insulin dependent diabetics. The sensor will provide quasi-continuous measurement of blood glucose levels and an alarm indicating pending hypo- or hyper- glycemia. The sensor will measure the near infrared absorption spectra across a blood vessel or vascular membrane at a multitude of discrete wavelengths (up to 18 wavelengths) and computing the glucose concentration using the absorption spectra based on an algorithm. The measurement will be taken once every 20 minutes unless specially programmed or when in an alarm situation. In these cases the measurement will be taken every 5 minutes. The initial project is aimed to design and build a breadboard glucose sensor unit and to demonstrate its ability to measure blood glucose in vivo in two dogs for a period of 3 months. Four sensor heads will be implanted in each dog including sensor heads for: vein, arterial, interstitial and vascular membrane. In the next phase of the study, the investigator will design and build the miniaturized implantable long term (5 years) glucose sensor for implantation in human. These sensors will be tested in dogs for one year and in people on acute basis.

该提案的目标是开发和商业化 胰岛素依赖者的长期植入式红外葡萄糖传感器 糖尿病人 该传感器将提供准连续测量， 血糖水平和指示即将发生的低血糖或高血糖的警报， - 是的 传感器将测量近红外吸收光谱 在多个离散的血管或血管膜上 波长（最多18个波长）和计算葡萄糖 基于算法使用吸收光谱来确定浓度。的 每20分钟测量一次，除非特别 或在报警情况下。 在这些情况下 每5分钟测量一次。 最初的项目旨在 设计和构建试验板葡萄糖传感器单元，并演示 其在一段时间内测量两只狗体内血糖的能力 3个月。 将在每只犬中植入四个传感器头，包括 传感器头：静脉、动脉、间质和血管膜。 在下一阶段的研究中，研究人员将设计和建造 微型植入式长期（5年）葡萄糖传感器， 植入人体。 这些传感器将在狗身上进行测试， 年和人在急性基础上。