METABOLISM IN GAMMA-GLUTAMY1 TRANSPEPTIDASE DEFICT MICE

GAMMA-GLUTAMY1 转肽酶缺陷小鼠的代谢

• 批准号: 2882839
• 负责人: Michael Lieberman
• 金额: $ 21.55万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2882839
• 关键词: aminoacid metabolism; drug metabolism; endotoxins; enzyme activity; genetically modified animals; glutathione; laboratory mouse; liver disorder; methylmercury; postnatal growth disorder; prenatal growth disorder; protein glutamine gamma glutamyltransferase; protein metabolism; sex development disorder; tumor necrosis factor alpha

DESCRIPTION: The principal investigator has recently generated mice that lack g-glutamyl transpeptidase (hereafter referred to as GGT), a critical enzyme in the g-glutamy cycle and glutathione metabolism. He now aims to use these GGT- deficient mice for four purposes: 1) to determine why deficient mice lag in growth and sexual maturation; 2) if deficient mice contain other GGT-like activities; 3) to more fully characterize the role of GGT in glutathione and amino acid metabolism; and 4) to examine the role of GGT metabolic pathways in two induced disease states, galactosamine/endotoxin induced liver injury and methylmercury metabolism and toxicity.

描述：首席研究员最近培育的小鼠