MACULAR CELL DEATH AND THE RETINAL PIGMENT EPITHELIUM

黄斑细胞死亡和视网膜色素上皮

• 批准号: 2839781
• 负责人: ANNETTE BAICH
• 金额: $ 9.22万
• 依托单位: SOUTHERN ILLINOIS UNIV AT EDWARDSVILLE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2004-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2839781
• 关键词: apoptosis; beta glucuronidase; cathepsin D; cell death; chick embryo; enzyme activity; human tissue; macular degeneration; macular drusen; necrosis; organ culture; phagocytosis; retinal pigment epithelium

DESCRIPTION (Adapted from applicant's abstract): Age-related macular degeneration (ARMD) is the primary cause of blindness in people over age 65 years. The disease results in the loss of photoreceptor cells and pigmented epithelium in the affected area. This project is designed to gain some understanding of the origin of ARMD by examining the effect of endogenous metabolites on the survival of the pigment epithelium of the eye.

描述（改编自申请人摘要）：视网膜相关黄斑 老年痴呆症（ARMD）是65岁以上人群失明的主要原因 年这种疾病导致光感受器细胞和色素沉着的损失。 受影响区域的上皮细胞。该项目旨在获得一些 了解ARMD的起源，通过检查内源性 代谢物对眼睛色素上皮细胞存活的影响。