肌动蛋白依赖的细胞器运动机制-猫眼课题宝

肌动蛋白依赖的细胞器运动机制

批准号：

2842282

负责人：

CHRISTINA A KING-SMITH

金额：

$9.23万

依托单位：

SAINT JOSEPH'S UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1999

资助国家：

美国

项目状态：

已结题

起止时间：

1999-07-01 至 2002-06-30

来源：

https://reporter.nih.gov/project-details/2842282

关键词：

Osteichthyes actins apical membrane cellular polarity electron microscopy granule intracellular transport microfilaments myosins organelles pigments protein localization stainings

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DESCRIPTION (adapted from investigator's abstract): The objective of the proposed research is to characterize the mechanism of actin-dependent pigment granule motility in RPE cells of teleosts. A model proposing that centripetal aggregation of pigment granules is linked to centripetal flow of actin filaments while centrifugal dispersion of pigment granules is affected along actin filaments via myosin motors, will be tested. Specific aims are to 1) characterize the ultrastuctural organization of F actin in RPE cells, 2) determine the polarity of actin filaments in RPE apical projections via S1 labeling, 3) determine whether particles attached to the surface of RPE cells undergo centripetal transport and 4) localize myosins VI and VIIa in RPE cells.

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