9TH INTERNATIONAL CONFERENCE ON BIOLOGICAL INORGANIC CHE

第九届国际生物无机化学会议

• 批准号: 2885606
• 负责人: MARIAN T. STANKOVICH
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2885606
• 关键词: biochemistry; meeting /conference /symposium; metal metabolism; metalloenzyme; metals

DESCRIPTION (taken from the application) Funds are requested to subsidize the cost of registration for postdoctoral associates and graduate students who will attend the Ninth International Conference on Biological Inorganic Chemistry (ICBIC9) on July I I-16, 1999 in Minneapolis, Minnesota. The ICBIC conferences held biennially in different parts of the world are the premier conferences in biological inorganic chemistry. Their purpose is to bring biochemists and biologists who use a variety of techniques to investigate the role of metal ions (from metalloenzyme structure and mechanisms to gene regulation) together with inorganic chemists who build model compounds to mimic these systems and provide further insights. This meeting attracts leaders in this very active field of research. There are many recent findings that metalloenzymes play important roles in metabolism and that defects in these proteins can cause disease. By studying the structure-activity relationships of these proteins and their inhibition and inactivation mechanisms, we are beginning to understand the structural bases of disease. We are trying to broaden the scope of our conference by including pharmaceutical people and those interested in disease states. Accordingly, we have set up sessions that put speakers together along nontraditional lines. Rather than categorizing sessions according to active site metal as in the two previous ICBICs, most sessions will emphasize functional similarities. Topics of possible interest to NIH are: 1) metal cofactor assembly, 2) protein radicals, 3) molecular oxygen activation and oxygen intermediates, 4) sensing and signaling, 5) metal metabolism, 6) ribozymes, 7) metals in medicine, 8) peptide processing, 9) long-range transfer, and 10) molecular oxygen toxicity There are sessions on metal metabolism and two speakers are leaders in the ferritin field: Elizabeth Theil, and Annie Powell (University of Norwich) who works on ferritin models. In addition, the program is heavily slanted towards iron containing proteins, and understanding their chemistry is the focus of our conference. Specifically, one speaker, Eckard Munck, is using Mossbauer spectroscopy to follow iron metabolism in cells, and another, Jerry Kaplan, is studying iron metabolism in yeast as a model for metal diseases in more advanced organisms. With respect to the broader goals of NIDDK, Dr. Alan Shaver of Montreal is speaking on insulin mimetics, and proteins related to Wilson's disease, Menke's disease and diphtheria are discussed in the session "Metalloproteins in Disease". Finally, some lecturers are supported by NIDDK such as Ed Solomon (a plenary lecturer), Bob Hausinger, Jerry Kaplan, Frank Raushel, Elizabeth Theil, and Joan Valentine.

描述（取自应用程序） 申请资助博士后注册费用 将参加第九届国际 生物无机化学会议（ICBIC 9）于1999年7月16日在 明尼阿波利斯，明尼苏达州。ICBIC每两年举行一次会议， 在世界各地，生物无机的主要会议 化学.他们的目的是让生物化学家和生物学家 各种技术来研究金属离子的作用（从金属酶 结构和基因调控机制）与无机化学家 他们构建模型化合物来模拟这些系统，并提供进一步的见解。 这次会议吸引了这一非常活跃的研究领域的领导者。 近年来的研究发现，金属酶在细胞凋亡中起着重要的作用。 这些蛋白质的缺陷会导致疾病。通过研究 这些蛋白质的结构-活性关系及其抑制作用， 失活机制，我们开始了解的结构基础 疾病 我们正试图扩大会议的范围， 制药人和那些对疾病状态感兴趣的人。因此我们 已经建立了会议，把发言者聚集在一起沿着非传统路线。 而不是像两个中那样根据活动部位金属对会话进行分类 以往的ICBIC，大多数会议将强调功能相似性。主题 NIH可能感兴趣的是：1）金属辅因子组装，2）蛋白质 自由基，3）分子氧活化和氧中间体，4）传感 和信号传导，5）金属代谢，6）核酶，7）医学中的金属，8） 肽加工，9）长距离转移，和10）分子氧毒性 有关于金属代谢的会议，两位发言者是 铁蛋白领域：伊丽莎白·泰尔和安妮·鲍威尔（诺维奇大学）， 在铁蛋白模型上工作。此外，该计划严重倾向于 含铁蛋白质，了解它们的化学性质是我们的重点 会议具体来说，一个发言者，埃卡德芒克，是使用穆斯堡尔 光谱学来跟踪细胞中的铁代谢，另一个，杰里卡普兰， 研究酵母中的铁代谢作为金属疾病的模型， 先进的有机体。关于NIDDK更广泛的目标，Alan Shaver博士 蒙特利尔的一位教授正在谈论胰岛素模拟物，以及与威尔逊氏病相关的蛋白质。 疾病，门克氏病和白喉进行了讨论会议 “疾病中的金属蛋白”。最后，NIDDK支持一些讲师 如艾德所罗门（全体会议讲师）、鲍勃豪辛格、杰里卡普兰、弗兰克 作者声明：John W.