9TH INTERNATIONAL CONFERENCE ON BIOLOGICAL INORGANIC CHE

描述(取自应用程序) 请拨资金以补贴博士后注册费用 将参加第九届国际会议的助理和研究生 1999年7月I-16日生物无机化学会议(ICBIC9) 明尼苏达州明尼阿波利斯。ICBIC会议每两年在不同的 世界部分地区是生物无机的主要会议 化学反应。他们的目的是让使用一种 研究金属离子(来自金属酶)作用的各种技术 基因调控的结构和机制)与无机化学家 他们建立了模拟这些系统的模型化合物，并提供了进一步的见解。 这次会议吸引了这一非常活跃的研究领域的领导者。 最近的许多发现表明，金属酶在 新陈代谢，这些蛋白质的缺陷会导致疾病。通过研究 这些蛋白质的构效关系及其抑制作用 失活机制，我们开始了解其结构基础 疾病。 我们正在努力扩大我们会议的范围，包括 制药人员和那些对疾病状态感兴趣的人。因此，我们 已经设立了会议，让演讲者沿着非传统的路线聚集在一起。 而不是像在两个版本中那样，根据活动站点金属对会话进行分类 在以往的ICBIC会议上，大多数会议都会强调功能上的相似性。主题 NIH可能感兴趣的是：1)金属辅因子组装，2)蛋白质 自由基，3)分子氧活化和氧中间体，4)传感 和信号，5)金属代谢，6)核酶，7)药物中的金属，8) 多肽加工、远距离转移和分子氧毒性 有关于金属新陈代谢的会议，两位演讲者是 铁蛋白领域：伊丽莎白·泰尔和安妮·鲍威尔(诺维奇大学) 研究铁蛋白模型。此外，该计划严重倾向于 含有铁的蛋白质，并了解它们的化学是我们的重点 会议。具体地说，演讲者埃卡德·蒙克正在使用穆斯堡尔 另一位科学家曾傑瑞·卡普兰则是 研究酵母中的铁代谢作为金属疾病的模型 高级有机体。关于NIDDK的更广泛目标，Alan Shaver博士 正在就胰岛素模拟物以及与威尔逊病相关的蛋白质发表演讲 会议讨论了疾病、门克氏病和白喉。 《疾病中的金属蛋白》。最后，一些讲师得到了NIDDK的支持 如埃德·所罗门(全体讲师)、鲍勃·豪辛格、曾傑瑞·卡普兰、弗兰克 劳谢尔、伊丽莎白·泰尔和琼·瓦伦丁。

DESCRIPTION (taken from the application) Funds are requested to subsidize the cost of registration for postdoctoral associates and graduate students who will attend the Ninth International Conference on Biological Inorganic Chemistry (ICBIC9) on July I I-16, 1999 in Minneapolis, Minnesota. The ICBIC conferences held biennially in different parts of the world are the premier conferences in biological inorganic chemistry. Their purpose is to bring biochemists and biologists who use a variety of techniques to investigate the role of metal ions (from metalloenzyme structure and mechanisms to gene regulation) together with inorganic chemists who build model compounds to mimic these systems and provide further insights. This meeting attracts leaders in this very active field of research. There are many recent findings that metalloenzymes play important roles in metabolism and that defects in these proteins can cause disease. By studying the structure-activity relationships of these proteins and their inhibition and inactivation mechanisms, we are beginning to understand the structural bases of disease. We are trying to broaden the scope of our conference by including pharmaceutical people and those interested in disease states. Accordingly, we have set up sessions that put speakers together along nontraditional lines. Rather than categorizing sessions according to active site metal as in the two previous ICBICs, most sessions will emphasize functional similarities. Topics of possible interest to NIH are: 1) metal cofactor assembly, 2) protein radicals, 3) molecular oxygen activation and oxygen intermediates, 4) sensing and signaling, 5) metal metabolism, 6) ribozymes, 7) metals in medicine, 8) peptide processing, 9) long-range transfer, and 10) molecular oxygen toxicity There are sessions on metal metabolism and two speakers are leaders in the ferritin field: Elizabeth Theil, and Annie Powell (University of Norwich) who works on ferritin models. In addition, the program is heavily slanted towards iron containing proteins, and understanding their chemistry is the focus of our conference. Specifically, one speaker, Eckard Munck, is using Mossbauer spectroscopy to follow iron metabolism in cells, and another, Jerry Kaplan, is studying iron metabolism in yeast as a model for metal diseases in more advanced organisms. With respect to the broader goals of NIDDK, Dr. Alan Shaver of Montreal is speaking on insulin mimetics, and proteins related to Wilson's disease, Menke's disease and diphtheria are discussed in the session "Metalloproteins in Disease". Finally, some lecturers are supported by NIDDK such as Ed Solomon (a plenary lecturer), Bob Hausinger, Jerry Kaplan, Frank Raushel, Elizabeth Theil, and Joan Valentine.