9TH INTERNATIONAL CONFERENCE ON BIOLOGICAL INORGANIC CHE

描述（摘自申请表） 申请资金补贴博士后注册费用 将参加第九届国际会议的同事和研究生 生物无机化学会议 (ICBIC9) 于 1999 年 7 月 I-16 日在 明尼苏达州明尼阿波利斯。 ICBIC会议每两年在不同地点举行 世界部分地区是生物无机领域的重要会议 化学。他们的目的是让生物化学家和生物学家使用 研究金属离子作用的多种技术（来自金属酶 基因调控的结构和机制）与无机化学家一起 他们构建模型化合物来模拟这些系统并提供进一步的见解。 这次会议吸引了这个非常活跃的研究领域的领导者。 最近的许多发现表明金属酶在 新陈代谢以及这些蛋白质的缺陷会导致疾病。通过学习 这些蛋白质的结构-活性关系及其抑制作用 失活机制，我们开始了解其结构基础 疾病。 我们正在努力扩大会议的范围，包括 制药人员和对疾病状态感兴趣的人。据此，我们 设立了一些会议，以非传统方式将发言者聚集在一起。 而不是像两个中那样根据活动站点金属对会话进行分类 以前的 ICBIC 中，大多数会议都会强调功能相似性。主题 NIH 可能感兴趣的是：1) 金属辅因子组装，2) 蛋白质 自由基，3) 分子氧活化和氧中间体，4) 传感 和信号传导，5) 金属代谢，6) 核酶，7) 医学中的金属，8) 肽加工，9) 远距离转移，10) 分子氧毒性 有关于金属代谢的会议，两位演讲者是该领域的领导者 铁蛋白领域：Elizabeth Theil 和 Annie Powell（诺维奇大学） 适用于铁蛋白模型。此外，该计划严重偏向于 含铁蛋白质，了解它们的化学性质是我们的重点 会议。具体来说，一位演讲者 Eckard Munck 正在使用穆斯堡尔 光谱法追踪细胞中的铁代谢，另一位，杰里·卡普兰（Jerry Kaplan），是 研究酵母中的铁代谢作为金属疾病的模型 先进的有机体。关于 NIDDK 的更广泛目标，Alan Shaver 博士 蒙特利尔正在谈论胰岛素模拟物和与威尔逊氏病相关的蛋白质 会议讨论了疾病、门克氏病和白喉 “疾病中的金属蛋白”。最后，部分讲师得到NIDDK的支持 例如 Ed Solomon（全体讲师）、Bob Hausinger、Jerry Kaplan、Frank 劳谢尔、伊丽莎白·泰尔和琼·瓦伦丁。

DESCRIPTION (taken from the application) Funds are requested to subsidize the cost of registration for postdoctoral associates and graduate students who will attend the Ninth International Conference on Biological Inorganic Chemistry (ICBIC9) on July I I-16, 1999 in Minneapolis, Minnesota. The ICBIC conferences held biennially in different parts of the world are the premier conferences in biological inorganic chemistry. Their purpose is to bring biochemists and biologists who use a variety of techniques to investigate the role of metal ions (from metalloenzyme structure and mechanisms to gene regulation) together with inorganic chemists who build model compounds to mimic these systems and provide further insights. This meeting attracts leaders in this very active field of research. There are many recent findings that metalloenzymes play important roles in metabolism and that defects in these proteins can cause disease. By studying the structure-activity relationships of these proteins and their inhibition and inactivation mechanisms, we are beginning to understand the structural bases of disease. We are trying to broaden the scope of our conference by including pharmaceutical people and those interested in disease states. Accordingly, we have set up sessions that put speakers together along nontraditional lines. Rather than categorizing sessions according to active site metal as in the two previous ICBICs, most sessions will emphasize functional similarities. Topics of possible interest to NIH are: 1) metal cofactor assembly, 2) protein radicals, 3) molecular oxygen activation and oxygen intermediates, 4) sensing and signaling, 5) metal metabolism, 6) ribozymes, 7) metals in medicine, 8) peptide processing, 9) long-range transfer, and 10) molecular oxygen toxicity There are sessions on metal metabolism and two speakers are leaders in the ferritin field: Elizabeth Theil, and Annie Powell (University of Norwich) who works on ferritin models. In addition, the program is heavily slanted towards iron containing proteins, and understanding their chemistry is the focus of our conference. Specifically, one speaker, Eckard Munck, is using Mossbauer spectroscopy to follow iron metabolism in cells, and another, Jerry Kaplan, is studying iron metabolism in yeast as a model for metal diseases in more advanced organisms. With respect to the broader goals of NIDDK, Dr. Alan Shaver of Montreal is speaking on insulin mimetics, and proteins related to Wilson's disease, Menke's disease and diphtheria are discussed in the session "Metalloproteins in Disease". Finally, some lecturers are supported by NIDDK such as Ed Solomon (a plenary lecturer), Bob Hausinger, Jerry Kaplan, Frank Raushel, Elizabeth Theil, and Joan Valentine.