CONFERENCE ON THE CHEMISTRY AND BIOLOGY OF PEROXYNITRITE

过氧亚硝酸盐化学和生物学会议

• 批准号: 2885038
• 负责人: HARRY ISCHIROPOULOS
• 金额: $ 1.2万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-05 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2885038
• 关键词: biochemistry; cell biology; inflammation; meeting /conference /symposium; molecular pathology; neural degeneration; peroxynitrites; travel

This is a second international conference, the first conference was held in May of 1997 in Ascona, Switzerland and attracted 70 scientists from all over the world. An indication of the success of the 1997 conference was exceptional quality of presentations, the length and extent of discussions and most of all the lively and animated evening discussions. During these discussions, which I vividly recall to date, controversial issues regarding peroxynitrite were critically discussed and evaluated. The resounding success of the first meeting and the overwhelming desire of all the participants to attend another conference resulted in the decision to put together a second meeting. The meeting is sponsored by the Nitric Oxide Society (see letters). We anticipate that the second meeting will bring together approximately 100 scientists; chemists, biochemists, biologists, physicians, neuroscientists and molecular biologists. The format will be similar to the first meeting and of Gordon conferences, with morning oral presentations followed by group discussions in the evening. The objectives will be to exchange information and engage in discussions regarding the chemistry, biology and medical applications of peroxynitrite. Peroxynitrite is the molecule formed by the reaction of nitric oxide and superoxide. A number of the chemical and biological functions of peroxynitrite have been described but almost monthly a new function or a possible role in human pathophysiology is reported. The number of laboratories contributing to investigations regarding peroxynitrite has grown over the years. A quick search in biomedical databases using peroxynitrite as the key word produced over 1,000 articles for the past eight years. However, the majority of the peer-reviewed articles (469) were published during the last two years following the Ascona meeting. Moreover, NIH currently funds a number of participants of the first meeting to work on peroxynitrite. Using the NIH search engine we found 86 projects that are currently funded by NIH to investigate the role of peroxynitrite in the pathogenic mechanism of neurodegenerative diseases, respiratory distress, cardiovascular disorders, cancer and a number of other disorders. Moreover, the most important advancements in this field are the recent evidence for the participation of peroxynitrite-mediated nitration of proteins in the pathogenesis of neurodegenerative diseases of aging.

这是第二次国际会议，第一次会议于1997年5月在瑞士阿斯科纳举行，吸引了来自世界各地的70名科学家。 1997年会议成功的迹象是演讲的卓越质量，讨论的时间和程度以及所有生动活泼的晚间讨论。 在这些讨论中，我生动地记得迄今为止，对过氧亚硝酸盐的有争议问题进行了严格的讨论和评估。 第一次会议的巨大成功以及所有参与者参加另一场会议的压倒性愿望导致决定举行第二次会议。 会议是由一氧化氮协会赞助的（请参阅字母）。我们预计第二次会议将汇集大约100位科学家。化学家，生物化学家，生物学家，医师，神经科学家和分子生物学家。 该格式将与第一次会议和戈登会议相似，早上口头演讲随后在晚上进行小组讨论。 这些目标将是交换信息并就过氧亚硝酸盐的化学，生物学和医学应用进行讨论。 过氧亚硝酸盐是由一氧化氮和超氧化物的反应形成的分子。已经描述了过氧亚硝酸盐的许多化学和生物学功能，但几乎每月都有新功能或在人类病理生理学中的作用。多年来，有关过氧亚硝酸盐的调查的实验室数量已增加。 在过去八年中，使用过氧亚硝酸盐作为关键字的生物医学数据库进行快速搜索。 但是，大多数同行评审的文章（469）是在Ascona会议后的最后两年发表的。此外，NIH目前为第一次会议的许多参与者提供了从事过氧亚硝酸盐的工作。 使用NIH搜索引擎，我们发现了86个项目，这些项目目前由NIH资助，研究过氧亚硝酸盐在神经退行性疾病，呼吸窘迫，心血管疾病，癌症和许多其他疾病的致病机制中的作用。此外，该领域中最重要的进步是过氧亚硝酸盐介导的蛋白质硝化参与衰老的神经退行性疾病发病机理的最新证据。