2013 Nitric Oxide Gordon Research Conference

描述(申请人提供)：GRC no 2013戈登一氧化氮研究会议旨在为生物学家、化学家、临床医生和其他科学家提供 关于NO生成系统的基本结构/功能关系的最新知识，以及NO作为生理学和病理生理学中的信号和效应分子的生物学知识。一个长期的目标是将这一知识用于开发基于一氧化氮的新疗法，特别是用于治疗和预防心血管疾病。本次研究会议每两年举行一次，下一次会议将于2013年2月17日至22日在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。预计将有来自学术界、政府和工业界的约160名参与者参加。请拨资金以资助与会者(即发言者/讨论领袖、杰出研究生/博士后候选人和其他从事非生物学领域工作的初级科学家)的会议注册费和旅费。选择演讲者是为了解决悬而未决的问题，覆盖该领域正在出现的新领域，并与高级和初级调查人员平衡该计划。为了特别宣传和展示年轻科学家的工作，邀请了12名才华横溢的初级研究人员(5名女性)进行全面演讲。 该领域的高级领导人将主持这些会议。会议将重点介绍关于 NO的形成和信号的调节。将深入讨论具有信号特性的化学相关氮氧化物物种，包括S-亚硝硫醇、亚硝酸盐和硝基脂肪酸。此外，治疗途径将重点介绍如何通过新描述的原则提高NO的生物利用度，以治疗和预防心血管和代谢性疾病。1998年诺贝尔奖获得者路易斯·J·伊格纳罗已友好地同意发表主旨演讲。此外，从提交给会议的摘要中挑选了两个突出的特色和主持的海报会议，一个是关于“当前争议和最新发现”的特别会议，另一个是“热点”会议，该会议鼓励新的或老牌调查人员在最后一刻提交令人兴奋的调查结果，最终向几名初级调查人员颁发奖项。这次会议的主要优势是有机会在高度集中但非正式的智力刺激气氛中进行跨学科互动。戈登关于NO的会议在提供指导和探索这一重要的基础和翻译研究领域的新前景方面发挥了至关重要的作用。

DESCRIPTION (provided by applicant): GRC NO 2013 The Gordon Research Conference on Nitric Oxide (NO) is designed to provide biologists, chemists, clinicians and other scientists with state-of-the-art knowledge on the basic structure/function relationships of NO generating systems, and the biology of NO as a signaling and effector molecule in physiology and pathophysiology. A long-term goal is to use this knowledge in development of novel NO based therapeutics in particular for treatment and prevention of cardiovascular disease. This research conference is held every two years and the next conference will take place at the Ventura Beach Marriott in Ventura, CA on Feb 17-22, 2013. Approximately 160 participants from academia, government and industry are expected to attend. Funds are requested to support conference registration and travel costs fees for participants (i.e. speakers/discussion leaders and for exceptional graduate students/post-doctoral candidates and other junior scientists working in the field of NO biology). The speakers have been selected to address unresolved questions and cover emerging new areas in the field and to balance the program with senior and junior investigators. In a specific effort to promote and showcase the work of younger scientists, 12 highly talented junior researchers (5 females) have been invited to give full talks. Senior leaders in the field will chair these sessions. Sessions will focus on novel insights on the regulation of NO formation and signaling. Chemically related nitrogen oxide species with signaling properties including S-nitrosothiols, nitrite and nitro fatty acids will be discussed in depth. In addition, therapeutic avenues will be covered with an emphasis on how enhancement of NO bioavailability via newly described principles might be used to treat and prevent cardiovascular and metabolic disease. 1998 Nobel laureate Louis J Ignarro has kindly agreed to present the Keynote Lecture. In addition, there are two prominently featured and moderated poster sessions selected from abstracts submitted to the meeting, a special session on "Current Controversies and Late-Breaking Findings" and a "Hot Topics" session that encourages last-minute submissions of exciting findings from new or established investigators culminating in awards given to several of the junior investigators. The main strength of this meeting is the opportunity for cross-disciplinary interactions in a highly focused, yet informal intellectually stimulating atmosphere. The Gordon Conference on NO plays an essential role in providing guidance and exploring new vistas in this important field of basic and translational research.