PATHOPHYSIOLOGIC CONSEQUENCES OF SMOKED SUBSTANCE ABUSE

这是一份申请资金，为FASE B提供部分支持 夏季研究会议，题为“肺病理生理学和 吸烟物质滥用的免疫后果。这将是第一次 全国会议特别关注肺和免疫 大麻和强效可卡因的后果，仅次于烟草， 在我们的社会中，吸烟最常见的物质排在第二和第三位。 因为这些物质对肺损伤和免疫的影响是 临床和基础研究的新兴领域--FASE B夏季 研究会议建议提供一个平台来讨论 采用多学科方法来理解 肺和免疫系统的病理生理学和病理生物学 吸食滥用物质的并发症 烟草。将就以下主题举行九次科学会议： 1)吸烟滥用物质的流行病学；2)化学和 烟熏物质的毒理学；3)给药途径，吸烟 地形和吸烟法：与药物生物利用度的关系； 4)吸烟物质对肺部症状和肺功能的影响； 5)烟熏物质对宿主免疫的影响；6)烟熏对宿主免疫的影响 对肺损伤和炎症的物质；7)吸烟的影响 致癌物质：生物学和流行病学证据；8) 大麻、可卡因和艾滋病毒感染；以及9)医用大麻： 肺和免疫后果的影响。演讲者和会议 主席将包括来自美国的36名研究人员和科学家(35人) 巴西(1)，包括8名女性和6名初级调查人员。一 海报部分(“吸烟物质和其他物质的健康后果” 吸入剂“)和两个讲习班(”设计中的方法学考虑“ 调查烟熏物质的生物影响的研究； (“大麻素的治疗潜力”)，其中 约25名学生、博士后和其他实习生以及初级教职员工 都会参与其中。本提案要求的资金用于支付旅费。 讲台演讲者以及25名学生和年轻人的费用 参加招贴画会议和讲习班的调查人员。这个 资金的余额将从制药公司获得。 预计会议将在以下方面提供交流： 临床和基础科学家的广泛主题与 吸烟的大麻和可卡因的肺部和免疫后果 将激发创造性的研究。

This is an application for funds to provide partial support for a FASEB Summer Research Conference entitled, "Pulmonary Pathophysiologic and Immune Consequences of Smoked Substance Abuse." This will be the first national conference focused specifically on the pulmonary and immune consequences of marijuana and crack cocaine, which, after tobacco, are the second and third most commonly smoked substances in our society. Since the effects of these substances on lung injury and immunity are an emerging area of both clinical and basic research, a FASEB Summer Research Conference is proposed to provide a platform to discuss the multidisciplinary approaches being employed to understand the pathophysiology and pathobiology of pulmonary and immune system complications of the smoking of abused substances in addition to tobacco. Nine scientific sessions will be held on the following topics: 1) Epidemiology of Smoked Substances of Abuse; 2) Chemistry and Toxicology of Smoked Substances; 3) Route of Administration, Smoking Topography and Smoking Methodology: Relation to Drug Bioavailability; 4) Impact of Smoked Substances on Pulmonary Symptoms and Lung Function; 5) Effect of Smoked Substances on Host Immunity; 6) Impact of Smoked Substances on Lung Injury and Inflammation; 7) Effects of Smoked Substances on Carcinogenesis: Biologic and Epidemiologic Evidence; 8) Marijuana, Cocaine and HIV infection; and 9) Medicinal Marijuana: Implications of Pulmonary and Immune Consequences. Speakers and session Chairs will include 36 investigators and scientists from the U.S.(35) and Brazil (1), including eight women and six junior investigators. One poster session ("Health Consequences of Smoked Substances and Other Inhalants") and two workshops ("Methodologic considerations in designing studies to investigate the biologic effects of smoked substances;" and "Therapeutic potential of cannabinoids") are also planned, in which about 25 students, postdoctoral and other trainees and junior faculty will participate. Funds requested in this proposal are to cover travel costs for the platform speakers and for 25 students and young investigators participating in the poster session and workshops. The balance of the funding will be obtained from Pharmaceutical Companies. It is expected that the conference will provide interchange between clinical and basic scientists on a broad range of topics related to the pulmonary and immune consequences of smoked marijuana and cocaine that will stimulate creative research.