GORDON CONFERENCE ON RNA EDITING

RNA 编辑戈登会议

• 批准号: 2849214
• 负责人: Ronald B. Emeson
• 金额: $ 2.09万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-20 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2849214
• 关键词: meeting /conference /symposium; posttranscriptional RNA processing; travel

A Gordon Conference on RNA editing is planned for January 24-29, 1999 at the Doubletree hotel in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA which results in the insertion, deletion or substitution of nucleotides. RNA editing can therefore correct, extend or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and ser e to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine tuning of protein function and biochemical pathways. Our understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross-fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences which are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly, questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. In this regard the cis-active regulatory elements and trans-acting factors mediating a number of editing processes are being evaluated at both the molecular and enetic level. Understanding the structure and function of these factors at the level of common or divergent features among the different editing systems is an important goal of the proposed Gordon Research Conference. Still other editing systems have yet to advance to in vitro systems or have been described only recently. The Gordon Research Conference will foster information and technology transfer which will promote developments in these areas. The cellular and molecular aspects of RNA editing regulation are also broadly being pursued at the level of evolution as well as the occurance of editing activities in different tissues and during development. The biological significance of RNA editing is a recurring theme throughout all aspects of the proposed conference. Finally, information about other forms of RNA processing is likely to have implications for understanding RNA editing mechanisms, and vice versa. Investigators working in other areas of RNA processing therefore will participate in appropriate sessions to stimulate exchange between these related fields.

关于RNA编辑的戈登会议计划于1999年1月24日至29日举行 在加州文图拉的双树酒店 RNA编辑是 RNA的共转录或转录后修饰，其导致 核苷酸的插入、缺失或取代。 RNA编辑可以 因此校正、扩展或多样化编码在 相应的基因组序列，并可以显着改变 修饰的RNA的功能。 例如，在 哺乳动物中枢神经系统可以增加 神经递质受体的表达，并有效地 调节神经信号通路。 同样重要的是， 许多RNA编辑过程的细胞调节， 提供发育、组织特异性和代谢微调 蛋白质功能和生物化学途径。 我们理解 RNA编辑的分子机制及其生物学意义 发生已经达到了一个关键阶段， 假设和实验方法是必不可少的重点， 未来十年的研究 有许多共同的问题和实验目标， 尽管生物体的多样性， 其中发生编辑，序列中明显的差异 其被修改。 对于理解每次编辑都很重要 系统是对被修饰的RNA底物的基本描述 通过这些过程。 同样，普遍感兴趣的问题 有关的机制，特异性，保真度和持续性， RNA编辑可以通过生物化学和生物化学的组合来解决。 分子生物学技术的发展， 体外编辑系统。 在这方面，顺式活性调节 元素和trans-acting因素介导的一些编辑 目前正在分子和遗传水平上对这些进程进行评估。 了解这些因素的结构和功能， 不同编辑之间的共性或差异性水平 系统是戈登研究所的一个重要目标 会议 还有一些编辑系统尚未发展到 体外系统或最近才被描述。 戈登 研究会议将促进信息和技术转让 这将促进这些领域的发展。 RNA编辑调控的细胞和分子方面也是 在进化的层面上， 编辑活动在不同组织中的发生， 发展 RNA编辑的生物学意义是 在拟议的会议的所有方面反复出现的主题。 最后，关于其他形式的RNA加工的信息可能会 对理解RNA编辑机制有意义， 亦然 在RNA加工的其他领域工作的研究人员 因此，将参加适当的会议，以促进 这些相关领域的交流。