GORDON RESEARCH CONFERENCE ON RNA EDITING

戈登 RNA 编辑研究会议

• 批准号: 6228523
• 负责人: Ronald B. Emeson
• 金额: $ 2.88万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-21 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6228523
• 关键词: RNA; meeting /conference /symposium; posttranscriptional RNA processing; travel

DESCRIPTION (from the application): Gordon Research Conferences on RNA Editing are planned for January, 2001 and January 2003 in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA, which results in the insertion, deletion, or substitution of nucleotides. RNA editing can therefore correct, extend, or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and serve to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine-tuning of protein function and biochemical pathways. Our understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences that are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. In this regard, the cis-active regulatory elements and trans- acting factors mediating a number of editing processes are being evaluated at both the molecular and genetic level. Understanding the structure and function of these factors at the level of common or divergent features among the different editing systems is an important goal of the proposed Gordon Research Conference. Still other editing systems have yet to advance to in vitro systems or have been described only recently. The Gordon Research Conference will foster information and technology transfer which will promote developments in these areas. The cellular and molecular aspects of RNA editing regulation are also broadly being examined at the evolutionary and developmental levels, as well as in multiple tissues and diverse organisms. The biological significance of RNA editing is a recurring theme throughout all aspects of the proposed conference. Information about other RNA processing events is also likely to have implications for understanding RNA editing mechanisms, and investigators working in other areas of RNA processing therefore will participate in appropriate sessions to stimulate exchange between these related fields.

来源：Gordon Research Conferences on RNA Editing 计划于2001年1月和2003年1月在加州的文图拉举行。RNA 编辑是RNA的共转录或转录后修饰， 在核苷酸的插入、缺失或取代中。RNA编辑可以 因此，校正、扩展或多样化编码在 相应的基因组序列，并可以显着改变的功能， 修饰的RNA例如，哺乳动物中枢神经系统内的编辑事件 系统可以增加神经递质受体表达的多样性， 用于有效地调节神经元信号传导途径。同样重要 是许多RNA编辑过程的细胞调节， 用于蛋白质的发育、组织特异性和代谢微调 功能和生化途径。我们对分子机制的理解 潜在的RNA编辑及其生物学发生已经达到了一个关键的阶段， 假设和实验方法交叉受精的阶段， 这是未来十年研究的重点。 研究人员中存在许多常见问题和实验目标 RNA编辑，尽管其中发生编辑的生物体的多样性， 修饰后的序列中明显的不同之处。重要的 理解每个编辑系统是对RNA的基本描述， 通过这些工艺改性的基材。类似的问题一般 关于机制，特异性，保真度和持续性的兴趣， RNA编辑可以通过生物化学和分子生物学的结合来解决。 生物技术与体外编辑系统的发展相结合。 在这方面，顺式活性调节元件和反式作用因子 调解一些编辑过程正在评估双方的 分子和基因水平。了解这些的结构和功能 在不同层次上的共同或不同特征的因素 编辑系统是戈登研究所提出的一个重要目标 会议还有其他编辑系统尚未发展到体外系统 或者最近才被描述。戈登研究会议将 促进信息和技术转让，促进以下领域的发展 这些地区 RNA编辑调控的细胞和分子方面也被广泛讨论。 在进化和发展的层面上，以及在 多种组织和多种生物体。RNA的生物学意义 编辑是拟议会议所有方面的一个反复出现的主题。 关于其他RNA加工事件的信息也可能有 对理解RNA编辑机制的影响，以及研究人员 在RNA加工的其他领域工作，因此将参与 适当的会议，以促进这些相关领域之间的交流。