GORDON RESEARCH CONFERENCE ON RNA EDITING

描述(来自应用程序)：关于RNA编辑的戈登研究会议 计划于2001年1月和2003年1月在加利福尼亚州文图拉举行。核糖核酸 编辑是RNA的协同或转录后修饰，其结果是 核苷酸的插入、缺失或替换。RNA编辑可以 因此，请更正、扩展或多样化 相应的基因组序列并可以显著改变细胞的功能 经过修饰的RNA。例如，编辑哺乳动物中枢神经内的事件 系统可增加神经递质受体表达的多样性和 用来有效地调节神经元信号通路。同样重要 是许多RNA编辑过程的细胞调节，它提供了 用于蛋白质的发育、组织特异性和代谢微调 功能和生化途径。我们对分子机制的理解 潜在的RNA编辑及其生物发生已经到了关键时刻 假说和实验方法交叉受精的阶段 对下一个十年研究的重点是至关重要的。 在研究人员中有许多共同的问题和实验目标 RNA编辑，尽管发生编辑的生物体的多样性，并且 被修改的序列的明显不同之处。重要的是 对每个编辑系统的了解是对RNA的基本描述 经过这些工艺修饰的底物。类似地，一般性问题 感兴趣的机制，特异性，保真度和可加工性 RNA编辑可以用生化和分子相结合的方法来解决 生物技术与体外编辑系统的发展相结合。 在这方面，顺式活性调节元件和反式作用因素 调解多个编辑过程正在进行评估， 分子和遗传水平。了解这些组件的结构和功能 不同组织之间共同或不同特征水平上的因素 编辑系统是戈登研究计划的一个重要目标 会议。还有其他编辑系统尚未发展到体外系统 或者直到最近才被描述过。戈登研究会议将 促进信息和技术转让，这将促进 这些区域。 RNA编辑调控的细胞和分子方面也是广泛的 在进化和发展层面进行审查，以及在 多个组织和不同的生物。RNA的生物学意义 编辑是贯穿拟议会议所有方面的一个反复出现的主题。 有关其他RNA处理事件的信息也可能具有 理解RNA编辑机制的含义，以及研究人员 因此，从事RNA处理的其他领域的工作将参与 适当的会议，以促进这些相关领域之间的交流。

DESCRIPTION (from the application): Gordon Research Conferences on RNA Editing are planned for January, 2001 and January 2003 in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA, which results in the insertion, deletion, or substitution of nucleotides. RNA editing can therefore correct, extend, or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and serve to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine-tuning of protein function and biochemical pathways. Our understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences that are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. In this regard, the cis-active regulatory elements and trans- acting factors mediating a number of editing processes are being evaluated at both the molecular and genetic level. Understanding the structure and function of these factors at the level of common or divergent features among the different editing systems is an important goal of the proposed Gordon Research Conference. Still other editing systems have yet to advance to in vitro systems or have been described only recently. The Gordon Research Conference will foster information and technology transfer which will promote developments in these areas. The cellular and molecular aspects of RNA editing regulation are also broadly being examined at the evolutionary and developmental levels, as well as in multiple tissues and diverse organisms. The biological significance of RNA editing is a recurring theme throughout all aspects of the proposed conference. Information about other RNA processing events is also likely to have implications for understanding RNA editing mechanisms, and investigators working in other areas of RNA processing therefore will participate in appropriate sessions to stimulate exchange between these related fields.