CONFERENCE--MOLECULAR & CELL BIOLOGY OF TRANSPLANTATION

在过去的半个世纪中，移植和免疫学领域遇到了许多相同的挑战，并在基础和临床领域共同发展。 例如，对人类和实验动物移植物命运的观察为免疫遗传学和细胞免疫学领域提供了基础。 与此同时，免疫学的基础研究已经产生了现代免疫抑制疗法，并为分析移植结果提供了工具。近年来，移植和免疫学的相互依赖性已经增长，因为关于移植排斥的分子基础的知识已经指出了免疫调节剂和耐受性的发展的新的、合理的方法。 异种移植领域的新兴努力证明了这一迅速进展，其中分子障碍的鉴定引起了移植供体的基因工程。 然而，在许多领域，移植的基础和临床研究还没有整合到最佳程度。 本次会议的目标是详细考虑免疫反应的分子生物学和细胞生理学，这些免疫反应有助于排斥移植和诱导免疫耐受。 会议将使那些从事临床和实验移植与那些参与基础研究重新考虑目前的知识基础，并确定未来的挑战和方法。

During the past half century, the fields of transplantation and immunology have met many of the same challenges and advanced together in both the basic and the clinical arenas. For example, observations regarding the fate of transplants in humans and experimental animals provided the foundation for the fields of immunogenetics and cellular immunology. At the same time, basic studies in immunology have given rise to modern immunosuppressive therapy and provided tools for analyzing transplant outcomes. The interdependence of transplantation and immunology has grown in recent years as knowledge concerning the molecular basis for transplant rejection has pointed to new, rational approaches to the development of immunomodulatory agents and tolerance. This rapid advance is exemplified by emerging efforts in the field of xenotransplantation, in which the identification of molecular hurdles has given rise to the genetic engineering of transplant donors. Still, as in many fields, the basic and clinical research in transplantation has not been integrated to an optimal extent. The goal of this conference is to consider in detail the molecular biology and cell physiology of immune responses which contribute to the rejection of transplants and to the induction of immunological tolerance. The conference will bring those engaged in clinical and experimental transplantation together with those involved in basic investigations to reconsider the current base of knowledge and identify future challenges and approaches.