Conference on Autoimmunity & Tolerance In Renal Disease

自身免疫会议

• 批准号: 6601963
• 负责人: Jeffrey L Platt
• 金额: $ 2万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6601963
• 关键词: autoimmune disorder; immune tolerance /unresponsiveness; kidney disorder; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): The proposed conference would be co-sponsored by the National Institutes of Health and the American Society of Nephrology. The conference program is being developed by the Basic Science Committee of the American Society of Nephrology. Recent advances in immunology have shed light on basic mechanisms underlying autoimmunity, tolerance, and on the means by which autoimmunity injures organs such as the kidney. While these advances have been considerable, only limited progresss has been made in connecting fundamental observations with the pathogenesis of glomerular and interstitial disease of the kidney. This conference will bring together scientists engaged in the study of basic immunology with investigators studying the manifestations of end-organ injury. Among the subjects to be taken up at the conference are new insights into the activation and function of T and B lymphocytes, the means by which the products of T and B lymphocytes contribute to tissue injury, and the control of lymphocyte function in autoimmune disease. New information regarding effector functions of antibodies and complement and control of complement will be presented. Focus will also be directed at how organs and tissues respond to immune challenge. Also to be considered, is how basic mechanisms can be exploited for therapeutic purposes. The synthesis emerging from this conference gives rise to new ideas, collaborations and approaches to dealing with autoimmunity and tolerance in the context of kidney disease. Topics to be discussed: * New insights into the activation and function of T and B lymphocytes; * Means by which the products of T and B lymphocytes contribute to tissue injury; * Control of lymphocyte function in autoimmune disease; * New information regarding effector functions of antibodies; * Complement and control of complement; * How basic mechanisms can be exploited for therapeutic purpose.

描述(由申请人提供)： 拟议的会议将由美国国立卫生研究院和美国肾脏学会共同主办。该会议计划是由美国肾脏学会基础科学委员会制定的。 免疫学的最新进展揭示了自身免疫、耐受的基本机制，以及自身免疫损害器官(如肾脏)的方式。虽然这些进展相当可观，但在将基础观察与肾小球和肾间质疾病的发病机制联系起来方面取得的进展有限。这次会议将汇集从事基础免疫学研究的科学家和研究终末器官损伤表现的研究人员。会议将讨论的主题包括对T和B淋巴细胞的激活和功能、T和B淋巴细胞产物促进组织损伤的途径以及自身免疫性疾病中淋巴细胞功能的控制的新见解。将介绍有关抗体和补体的效应器功能以及补体的控制的新信息。重点还将针对器官和组织如何应对免疫挑战。还需要考虑的是，如何将基本机制用于治疗目的。从这次会议中产生的综合提出了新的想法、合作和方法来处理肾脏疾病背景下的自身免疫和耐受问题。 将讨论的主题： *对T和B淋巴细胞的激活和功能的新见解； *T和B淋巴细胞产物对组织损伤的作用方式； *自身免疫性疾病中淋巴细胞功能的控制； *有关抗体效应器功能的新资料； *补充性和补充性的控制； *如何利用基本机制达到治疗目的。