Laboratory Core

实验室核心

• 批准号: 7124872
• 负责人: Jeffrey L Platt
• 金额: $ 17.65万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124872
• 关键词: biomedical facility; heart transplantation; immune tolerance /unresponsiveness; immunologic assay /test; immunopathology diagnosis; leukocyte activation /transformation; tissue /cell preparation; transplant rejection; transplantation immunology

The laboratory core will serve three functions for the program. First, the laboratory core will perform analysis of lymphocyte receptor repertoires using a method developed by Drs. Ogle, Platt, Cascalho, and West. Second, the core will obtain laboratory studies, such as measurement of viral load and autoantibody levels needed for two or more projects. Third, the core will provide a standardized review and coordination of analysis of tissue samples for diagnosis of rejection (or lack thereof), as relevant to the goals of the program or interactions between two or more projects.

实验室核心将为该计划提供三个功能。首先，实验室核心将使用Ogle、Platt、Cascalho和West博士开发的方法对淋巴细胞受体库进行分析。其次，核心将获得实验室研究，如两个或多个项目所需的病毒载量和自身抗体水平的测量。第三，核心将提供标准化的审查和协调组织样本的分析，以诊断排斥（或缺乏排斥），这与计划的目标或两个或多个项目之间的相互作用有关。