GENETIC EPIDEMIOLOGY--DEVELOPMENT OF CARDIOVASCULAR RISK
遗传流行病学——心血管风险的发展
基本信息
- 批准号:6044032
- 负责人:
- 金额:$ 11.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-08-01 至 2001-07-31
- 项目状态:已结题
- 来源:
- 关键词:cardiovascular disorder epidemiology clinical research comorbidity disease /disorder proneness /risk gender difference genetic models human data human population genetics hypertension longitudinal human study mathematical model model design /development obesity racial /ethnic difference twin /multiplet
项目摘要
DESCRIPTION: (Adapted from Investigator's Abstract) Obesity and
hypertension are two of the major risk factors for cardiovascular disease
(CVD) and those with obesity have a greater risk of hypertension. In
children and adolescents, high body mass index correlates with elevated
blood pressure. Genetic factors make a significant contribution to the
variation of obesity and hypertension. The investigators will address how
genetic and environmental factors influence the co-occurrence of obesity and
hypertension during development and aim to identify cardiovascular risk
factors in adolescence that will predict CVD in adults.
Genetically informative cardiovascular and anthropometric data from
childhood to young adulthood will help answer these questions. The
investigators have access to two major longitudinal population-based
adolescent twin-family datasets, the Medical College of Virginia Twin Study
[CVT] (Dr. R. Schieken) and the Leuven Longitudinal Twin Study [LLTS]
(Prof. Dr. G. Beunen). The CVT is a longitudinal population-based study of
Virginian 570 twin pairs (and parents) measured from age 11 to 17 on
cardiovascular risk factors. The LLTS is a longitudinal population-based
study of 105 Belgian twin pairs and parents with anthropometry,
cardiovascular and fitness assessments between ages 10 and 18.
Genetic epidemiologic methods provide information about the causes of the
variation and covariation, and the direction of causation between variables.
Availability of longitudinal twin-parent data further strengthens our
design.
The investigators will analyze anthropometric, cardiovascular, physiologic
and physical fitness data to investigate a series of critical issues about
the etiology, heterogeneity, comorbidity and developmental trajectories of
CVD risk factors, including obesity, hypertension and cardiovascular health.
With these two exceptional datasets, they will investigate the main
questions of this application: How do genes and environment act and
interact to create covariation between obesity and hypertension, and are the
genetic and environmental factors the same at all ages (from childhood to
late adolescence and adulthood) in both sexes? Areas of research will
include the following: causes of individual differences in anthropometric
and cardiovascular characteristics, their covariation and developmental
change or continuity in adolescence, parent-offspring transmission,
prediction of cardiovascular risk, and sex, race and population differences
in genetic and environmental contributions on cardiovascular risk factors.
The investigators point out that given that heart disease begins in
childhood, a better understanding of the development of cardiovascular risk
is vital for the treatment and prevention of CVD.
描述:(改编自研究者摘要)肥胖和
高血压是心血管疾病的两个主要危险因素
(CVD)肥胖者患高血压的风险更大。 在
儿童和青少年,高体重指数与升高
血压. 遗传因素对遗传的影响很大。
肥胖和高血压的变化。 调查人员将讨论如何
遗传和环境因素影响肥胖症的共同发生,
旨在确定心血管风险
青少年期的因素,将预测成年人的CVD。
遗传信息的心血管和人体测量数据,
从童年到青年期将有助于回答这些问题。 的
研究人员可以获得两个主要的纵向人口为基础的
青少年双胞胎家庭数据集,弗吉尼亚医学院双胞胎研究
[CVT](R. Schieken)和鲁汶纵向双胞胎研究(LLTS)
(G. Beunen)。 CVT是一项纵向人群研究,
哥伦比亚大学的570对双胞胎(和父母),从11岁到17岁,
心血管危险因素。 LLTS是一个基于人口的纵向
对105对比利时双胞胎及其父母进行了人体测量学研究,
10到18岁之间的心血管和健康评估。
遗传流行病学方法提供了有关的原因,
变异和协变,以及变量之间因果关系的方向。
纵向双亲数据的可用性进一步加强了我们的研究。
设计
研究人员将分析人体测量,心血管,生理
和身体健康数据来调查一系列关于
的病因、异质性、共病和发展轨迹,
心血管疾病危险因素,包括肥胖、高血压和心血管健康。
有了这两个特殊的数据集,他们将调查主要的
本应用程序的问题:基因和环境如何作用,
相互作用,在肥胖和高血压之间产生协变,
遗传和环境因素在所有年龄段(从童年到
青春期后期和成年期)在两性中? 研究领域将
包括:人体测量中个体差异的原因
和心血管特征,它们的协变和发育
青春期的变化或连续性,亲子传播,
心血管风险的预测,以及性别、种族和人群差异
遗传和环境因素对心血管危险因素的影响。
研究人员指出,鉴于心脏病始于
儿童时期,更好地了解心血管风险的发展
对于CVD的治疗和预防至关重要。
项目成果
期刊论文数量(0)
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专利数量(0)
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{{ truncateString('HERMINE H MAES', 18)}}的其他基金
Using a Genetic Approach to Understand Factors Influencing Resistance to Substance Use
使用遗传学方法了解影响药物使用耐药性的因素
- 批准号:
10677690 - 财政年份:2022
- 资助金额:
$ 11.56万 - 项目类别:
Using a Genetic Approach to Understand Factors Influencing Resistance to Substance Use
使用遗传学方法了解影响药物使用耐药性的因素
- 批准号:
10522411 - 财政年份:2022
- 资助金额:
$ 11.56万 - 项目类别:
GENETIC EPIDEMIOLOGY--DEVELOPMENT OF CARDIOVASCULAR RISK
遗传流行病学——心血管风险的发展
- 批准号:
2674302 - 财政年份:1998
- 资助金额:
$ 11.56万 - 项目类别:
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