GENETIC EPIDEMIOLOGY--DEVELOPMENT OF CARDIOVASCULAR RISK

描述：(改编自《调查者摘要》)肥胖和 高血压是心血管疾病的两个主要危险因素。 心血管疾病(CVD)和肥胖者患高血压的风险更大。在……里面 儿童和青少年，高体重指数与 血压。遗传因素在很大程度上导致了 肥胖和高血压的变异。调查人员将解决如何 遗传和环境因素影响肥胖和肥胖的并存 发展中的高血压，旨在识别心血管风险 青春期的因素将预测成人的心血管疾病。 遗传信息心血管和人体测量数据来自 从童年到成年将有助于回答这些问题。这个 调查人员可以接触到两个主要的纵向人口 弗吉尼亚医学院双胞胎青少年数据集 [CVT](R.Schieken博士)和鲁汶纵向孪生研究[LLTS] (G.Beunen教授)。CVT是一项基于人群的纵向研究 弗吉尼亚人570对双胞胎(和父母)从11岁到17岁测量 心血管危险因素。LLTS是一种以人口为基础的纵向 105对比利时双胞胎及其父母的人体测量研究 在10岁到18岁之间进行心血管和健康评估。 遗传流行病学方法提供了有关疾病原因的信息 变异和协变，以及变量之间的因果关系方向。 纵向双亲数据的可用性进一步加强了我们的 设计。 研究人员将分析人体测量学、心血管、生理学 和身体健康数据来调查一系列关键问题 本病的病因、异质性、共病及发展轨迹 心血管疾病的危险因素，包括肥胖、高血压和心血管健康。 有了这两个异常数据集，他们将调查主要的 这项应用的问题：基因和环境是如何作用的 相互作用，造成肥胖和高血压之间的协变性，并且是 遗传和环境因素在所有年龄段都是相同的(从童年到 青春期后期和成年期)在两性中？研究领域将 包括以下内容：人体测量中个体差异的原因 和心血管特征，它们的协变和发展 青春期的变化或延续，亲子传播， 心血管风险的预测，以及性别、种族和人口差异 在遗传和环境对心血管危险因素的贡献方面。 研究人员指出，鉴于心脏病始于 童年，更好地理解心血管风险的发展 对治疗和预防心血管疾病至关重要。

DESCRIPTION: (Adapted from Investigator's Abstract) Obesity and hypertension are two of the major risk factors for cardiovascular disease (CVD) and those with obesity have a greater risk of hypertension. In children and adolescents, high body mass index correlates with elevated blood pressure. Genetic factors make a significant contribution to the variation of obesity and hypertension. The investigators will address how genetic and environmental factors influence the co-occurrence of obesity and hypertension during development and aim to identify cardiovascular risk factors in adolescence that will predict CVD in adults. Genetically informative cardiovascular and anthropometric data from childhood to young adulthood will help answer these questions. The investigators have access to two major longitudinal population-based adolescent twin-family datasets, the Medical College of Virginia Twin Study [CVT] (Dr. R. Schieken) and the Leuven Longitudinal Twin Study [LLTS] (Prof. Dr. G. Beunen). The CVT is a longitudinal population-based study of Virginian 570 twin pairs (and parents) measured from age 11 to 17 on cardiovascular risk factors. The LLTS is a longitudinal population-based study of 105 Belgian twin pairs and parents with anthropometry, cardiovascular and fitness assessments between ages 10 and 18. Genetic epidemiologic methods provide information about the causes of the variation and covariation, and the direction of causation between variables. Availability of longitudinal twin-parent data further strengthens our design. The investigators will analyze anthropometric, cardiovascular, physiologic and physical fitness data to investigate a series of critical issues about the etiology, heterogeneity, comorbidity and developmental trajectories of CVD risk factors, including obesity, hypertension and cardiovascular health. With these two exceptional datasets, they will investigate the main questions of this application: How do genes and environment act and interact to create covariation between obesity and hypertension, and are the genetic and environmental factors the same at all ages (from childhood to late adolescence and adulthood) in both sexes? Areas of research will include the following: causes of individual differences in anthropometric and cardiovascular characteristics, their covariation and developmental change or continuity in adolescence, parent-offspring transmission, prediction of cardiovascular risk, and sex, race and population differences in genetic and environmental contributions on cardiovascular risk factors. The investigators point out that given that heart disease begins in childhood, a better understanding of the development of cardiovascular risk is vital for the treatment and prevention of CVD.