Tipping the balance from tolerance to immunity for the devil facial tumour

打破面部魔鬼肿瘤从耐受到免疫的平衡

• 批准号: DE180100484
• 负责人: Dr Andrew Flies
• 金额: $ 25.55万
• 依托单位: University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100484
• 关键词: Tipping; balance; tolerance; immunity; devil

This project aims to develop a single-shot vaccine for the Tasmanian devil facial tumour disease. The disease is an enigma because the transmissible tumours are simultaneously cancer, infections, and genetically mismatched tissue grafts. This project will focus on immune molecules that are revolutionising human oncology, and will develop techniques to understand and systematically test the function of these key molecules in Tasmanian devils. Understanding the role of these immune molecules will accelerate development of a vaccine to help save the devil and has the potential to shed light on general principles relating to how the immune system balances tolerance and immunity.

该项目旨在开发一种针对塔斯马尼亚魔鬼面部肿瘤疾病的单针疫苗。这种疾病是一个谜，因为可传播的肿瘤同时是癌症、感染和基因不匹配的组织移植物。这个项目将把重点放在正在给人类肿瘤学带来革命性变化的免疫分子上，并将开发技术来了解和系统地测试塔斯马尼亚魔鬼中这些关键分子的功能。了解这些免疫分子的作用将加快疫苗的开发，帮助拯救魔鬼，并有可能阐明与免疫系统如何平衡耐受性和免疫力有关的一般原则。