Metabolism and Metabolic Health Core
新陈代谢和代谢健康核心
基本信息
- 批准号:10588974
- 负责人:
- 金额:$ 18.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-01 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAnimalsApplications GrantsAreaBehaviorBioenergeticsBiological AssayBiomedical ResearchBody CompositionCatalogsClientClinical TrialsCollaborationsComplementComplexConsultationsContinuous Glucose MonitorCore AssemblyCoupledCouplingDataData SetDiabetes MellitusDigestionDual-Energy X-Ray AbsorptiometryEatingEnergy IntakeEnergy MetabolismEquipmentExerciseFeeding behaviorsFemaleFrequenciesFunctional disorderGenerationsGlucoseGoalsHealthHepaticHomeostasisHormonesHumanInfrastructureInstitutionLinkLipidsMacronutrients NutritionMeasuresMetabolicMetabolic DiseasesMetabolic dysfunctionMetabolic hormoneMetabolismMethodsMissionModelingMolecularMusNorepinephrineObesityOutcomeParticipantPatternPhenotypePhysiologyPlayProceduresProductionPublicationsRegulationReproducibilityResearchResearch DesignResearch PersonnelRoleScientistServicesSignal TransductionSpecialistStructureTechniquesTestingTissuesTrainingTriglyceride MetabolismTriglyceridesWeight GainWorkcomplex datadesignenergy balanceexperienceexperimental studyextreme temperaturefeedingflexibilityfrontierglucose metabolismglucose tolerancegut microbiomegut microbiotahormone sensitivityin vivoinnovationinstrumentationinsulin toleranceinterestmalemetabolic phenotypemetabolomicsmicrobiomemouse modelpre-clinicalprogramswhole body imaging
项目摘要
ABSTRACT—METABOLISM AND METABOLIC HEALTH (MMH) CORE
Investigators interested in mechanisms underlying the pathophysiology of obesity, diabetes and related
metabolic diseases will benefit from a comprehensive analysis of components regulating energy balance,
macronutrient combustion and metabolism in live animals. Simple tests that compare food intake to weight
gain, or that measure metabolically-relevant analytes from a single static condition, fail to fully capture nuanced
bioenergetic and metabolic phenotypes, changes in feeding behaviors, or alterations of body composition.
Therefore, the Metabolism and Metabolic Health (MMH) Core has been designed and structured to provide
investigators with expert consultation, state-of-the-art instrumentation, and technical support to assess—in live
mice—energy balance, energy intake (EI) and digestion, energy expenditure (EE), metabolic efficiency, EI-EE
coupling phenotypes, macronutrient metabolism, hormone action and secretion, body/tissue composition, and
associations with the microbiome and xenometabolome. The MMH Core will be service-oriented, client-facing,
and research-supportive. The MMH Core will be staffed by a Leader, co-Leader, Core Coordinator, Technical
Specialists, and 5 Scientific Consultants.
The mission of the MMH Core will be accomplished through the following 2 Specific Aims:
Specific Aim 1: Provide clients with innovative and unique assets and approaches to deeply-
characterize key nodes involved with energy balance, food intake, glucose and triglyceride
metabolism, metabolic hormone sensitivity, body composition and gut microbiota metabolism in live
mice.
Specific Aim 2: Provide clients with consultation services focused on study design and interpretation
of results in the areas of metabolic physiology, obesity, and diabetes.
Under these specific aims, the MMH Core will carry out the following activities:
• Providing acute, mid, and long -term assessments of EI and sensitivity to EI-regulating hormones in
male and female mice as models of diabetes, obesity, and other metabolic disorders;
• Offering a battery of bioenergetics and EE tests, including RER complex pattern and frequency
analysis, EE-EI coupling as a measure of energy balance regulation, and characterization of TNZ
and TNP, including under temperature extremes, norepinephrine, exercise, or timed meal
challenges;
• Conducting analyses of body composition by EchoMRI and PixiMus DEXA and studies of
macronutrient metabolism via glucose and insulin tolerance tests, continuous glucose monitoring,
and hepatic triglyceride production;
• Providing innovative and unique services to assess the microbiome and xenometabolome,
metabolic and feeding efficiency, and whole-body imaging to complement services obtained from
the PB Core;
• Assisting investigators to generate high-quality and reproducible research results for publications,
pilot data for grant proposals, and preclinical findings to inform human clinical trials;
• Being flexible and responsive to user requests for new and customizable assays and procedures;
• Participating in the Vibrant Program to assist and train a new generation of scientists with a tailored
focus toward underrepresented investigators and increasing diversity in biomedical research
Through their previous association with the MMPC, the investigators participating in the MMH Core have
proven expertise and capabilities in the study of energy metabolism, bioenergetics, body composition, glucose
and lipid homeostasis, food intake, metabolomics, and gut microbiota in live mice. When coupled with state-of-
the-art equipment, facilities, and core analytical labs at UC Davis, the MMH Core will be a unique and highly-
impactful scientific asset to national investigators interested in metabolic physiology and the pathophysiology of
diabetes and obesity.
代谢和代谢健康(MMH)核心
对肥胖、糖尿病及相关疾病的病理生理学机制感兴趣的研究者
代谢疾病将受益于调节能量平衡的组分的综合分析,
活动物体内大量营养素的燃烧和代谢。比较食物摄入量和体重的简单测试
增益或从单一静态条件测量代谢相关分析物,不能完全捕获细微差别
生物能量和代谢表型、摄食行为的变化或身体组成的改变。
因此,代谢和代谢健康(MMH)核心的设计和结构,
研究人员提供专家咨询、最先进的仪器和技术支持,以进行现场评估
小鼠能量平衡,能量摄入和消化,能量消耗,代谢效率
偶联表型、常量营养素代谢、激素作用和分泌、身体/组织组成,以及
与微生物组和异种代谢组的关联。MMH核心将面向服务,面向客户,
和研究支持。MMH核心将配备一名领导人、共同领导人、核心协调员、技术
专家和5名科学顾问。
MMH核心的使命将通过以下2个具体目标来实现:
具体目标1:为客户提供创新和独特的资产和方法,
表征涉及能量平衡、食物摄入、葡萄糖和甘油三酯的关键节点
肝脏代谢、代谢激素敏感性、身体组成和肠道微生物群代谢
小鼠
具体目标2:为客户提供专注于研究设计和解释的咨询服务
代谢生理学、肥胖症和糖尿病领域的研究成果。
根据这些具体目标,产妇保健核心方案将开展以下活动:
·提供急性、中期和长期的EI评估以及对EI调节激素的敏感性,
雄性和雌性小鼠作为糖尿病、肥胖症和其他代谢紊乱的模型;
·提供一系列生物能量学和EE测试,包括RER复杂模式和频率
分析,EE-EI耦合作为能量平衡调节的测量,以及TNZ的表征
和TNP,包括在极端温度下,去甲肾上腺素,运动或定时进餐
挑战;
·通过EchoMRI和PixiMus DEXA进行身体成分分析,
通过葡萄糖和胰岛素耐量试验的大量营养素代谢,连续葡萄糖监测,
和肝甘油三酯生成;
·提供创新和独特的服务,以评估微生物组和异种代谢组,
代谢和喂养效率,以及全身成像,以补充从
PB核心;
·协助研究人员为出版物产生高质量和可重复的研究结果,
用于资助提案的试点数据,以及为人类临床试验提供信息的临床前发现;
·灵活并响应用户对新的和可定制的测定和程序的请求;
·参与充满活力的计划,以帮助和培训新一代的科学家,
关注代表性不足的研究者和生物医学研究的日益多样化
通过他们以前与MMPC的联系,参与MMH核心的研究者已经
在研究能量代谢、生物能量学、身体成分、葡萄糖
和脂质稳态、食物摄入、代谢组学和肠道微生物群。当与国家的,
先进的设备,设施和核心分析实验室在加州大学戴维斯分校,MMH核心将是一个独特的,高度-
为对代谢生理学和疾病病理生理学感兴趣的国家研究人员提供有影响力的科学资产。
糖尿病和肥胖症。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sean Harrison Adams其他文献
Sean Harrison Adams的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sean Harrison Adams', 18)}}的其他基金
California Partnership for Personalized Nutrition
加州个性化营养合作伙伴关系
- 批准号:
10669429 - 财政年份:2022
- 资助金额:
$ 18.27万 - 项目类别:
California Partnership for Personalized Nutrition
加州个性化营养合作伙伴关系
- 批准号:
10386527 - 财政年份:2021
- 资助金额:
$ 18.27万 - 项目类别:
California Partnership for Personalized Nutrition
加州个性化营养合作伙伴关系
- 批准号:
10540243 - 财政年份:2021
- 资助金额:
$ 18.27万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
7809146 - 财政年份:2009
- 资助金额:
$ 18.27万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
8308909 - 财政年份:2008
- 资助金额:
$ 18.27万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
7688580 - 财政年份:2008
- 资助金额:
$ 18.27万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
8118833 - 财政年份:2008
- 资助金额:
$ 18.27万 - 项目类别:
Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
脂肪酸β-氧化的肌肉特异性生物标志物的鉴定
- 批准号:
7903969 - 财政年份:2008
- 资助金额:
$ 18.27万 - 项目类别:
Body Composition, Thermoregulation and food Intake Behavior Core
身体成分、体温调节和食物摄入行为核心
- 批准号:
8204177 - 财政年份:
- 资助金额:
$ 18.27万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 18.27万 - 项目类别:
Research Grant