Physiology of oxygen transport in the mammalian kidney

哺乳动物肾脏中氧运输的生理学

• 批准号: DP180103039
• 负责人: Prof Bruce Gardiner
• 金额: $ 27.45万
• 依托单位: Murdoch University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103039
• 关键词: Physiology; oxygen; transport; mammalian; kidney

This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology community, and potentially change the accepted story of oxygen homeostasis in the kidney. This will provide significant benefits, such as the provision of the foundational physiological science behind a determinant of kidney health and its flow-on impact to quality of life.

本项目旨在提高对肾组织氧调节的认识和对肾脏生理学的认识。哺乳动物肾脏接受的氧气比它使用或需要的要多，但肾脏组织通常是缺氧的。这个项目提出，氧运输到肾组织是由血管表面积限制。该项目期望生成肾生理学界目前缺失的解剖数据，并有可能改变肾中氧稳态的公认故事。这将提供显著的好处，例如提供肾脏健康决定因素背后的基础生理科学及其对生活质量的影响。