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Metabolic Physiology and Energy Balance Core

代谢生理学和能量平衡核心

基本信息

批准号：
10586204
负责人：
BARBARA B. KAHN
金额：
$ 18.35万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-15 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10586204
关键词：
Adipocytes Adipose tissue Affect Area Biological Body Composition Body Temperature Body Weight decreased Body measure procedure Bone Density Boston Carbon Dioxide Cell model Cells Communities Continuous Glucose Monitor Diabetes Mellitus Dose Dual-Energy X-Ray Absorptiometry Eating Endocrinology Ensure Equipment Fatty Acids Feedback Genes Genetic Vectors Genomics Glucose Goals Grant Homeostasis In Vitro Indirect Calorimetry Insulin Insulin Resistance Knock-in Lipids Lipolysis Measurement Measures Metabolic Metabolism Mission Modeling Mus Obesity Oxygen Consumption Pathway interactions Phenotype Physical activity Physiology Production Proteomics Quality Control Reproducibility Research Research Design Research Personnel Resolution Rodent Model Role Services Surveys Techniques Technology Training and Education Triglycerides United States National Institutes of Health Viral Vector Weight Gain awake blood glucose regulation design energy balance experience experimental study gene product glucose metabolism glucose transport glucose uptake in vivo insulin sensitivity knockout gene lipid metabolism member metabolic rate metabolomics mouse model overexpression respiratory response tool

项目摘要

METABOLIC PHYSIOLOGY AND ENERGY BALANCE CORE Project Summary/Abstract The main function of the Metabolic Physiology and Energy Balance Core is to perform experimental services to investigate alterations of glucose homeostasis, insulin sensitivity, lipid metabolism and body composition in rodent models of obesity and insulin resistance. Increasingly, the biologic roles of gene products and pathways emerging from genomic, proteomic, metabolomic and other discovery approaches are being queried by generating overexpression, gene knockout or knock-in of altered genes in rodent models. Thus, there is a growing need for characterization of new mouse models created by genetic or viral vector technologies. The Metabolic Physiology and Energy Balance Core is designed to meet the needs for characterization of rodent models that have alterations in glucose homeostasis, insulin action, and/or body composition and adiposity. The specific objectives of the Core are to carry out and interpret experiments for Core users aimed at investigating glucose homeostasis and energy balance. In vivo studies in awake mice include continuous glucose monitoring, measuring metabolic rates and energy balance by indirect calorimetry and body composition by EchoMRI and DEXA. Studies in primary adipocytes or adipose explants include glucose transport, metabolism, and lipolysis with assessment of insulin sensitivity. Services also include the differentiation of stromovascular cells into adipocytes and assessment of glucose uptake and insulin sensitivity. There is high demand for these services and we anticipate high utilization. The Core is actively utilized by BADERC members and other investigators in the Boston area. It enables investigators from other fields to carry out studies in the area of diabetes and metabolism that may not otherwise be feasible. Since the inception of the Core, we have received an increasing number of requests for services from investigators new to the field of metabolism, diabetes and obesity. The Core provides critical support for NIH grants for both new and established investigators. In many cases, the Core provides the tools that enable experts in other fields to apply their sophisticated techniques to metabolism research.

代谢生理学和能量平衡核心