Structure-based investigations into new modes of action for herbicides

基于结构的除草剂新作用模式研究

• 批准号: DE180101445
• 负责人: Dr Joel Haywood
• 金额: $ 25.82万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-04-02 至 2021-05-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180101445
• 关键词: Structure; based; investigations; into; new

This project aims to focus on identifying and providing protein structure information for new protein targets against which herbicides can be developed. Food security for a growing population relies on agriculture, which in turn relies on herbicides. Presently, herbicide efficacy is under serious threat from resistant weeds. In this project, innovative applications of chemical libraries and exploiting a little-known connection between plants and human parasites will help to resolve the structure of herbicide targets for the development of new herbicides to ensure future food security.

该项目旨在为新的蛋白质靶标确定和提供蛋白质结构信息，以针对这些靶标开发除草剂。不断增长的人口的粮食安全依赖于农业，而农业又依赖于除草剂。目前，除草剂的药效受到抗药性杂草的严重威胁。在该项目中，化学库的创新应用和利用植物和人类寄生虫之间鲜为人知的联系将有助于解决除草剂靶标的结构，以开发新的除草剂，以确保未来的粮食安全。