EQUIPMENT REQUEST

设备需求

• 批准号: 3059156
• 负责人: DONALD H MAUL
• 金额: $ 8.01万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1993-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3059156
• 关键词: animal colony; building /facility design /renovation

The intent of this animal resource improvement proposal is to allow the University to oontinue progress toward AAALAC accreditation which is progressing well with the help of two recent renovation grants from NIH. This proposal addresses the next project in our plan to become aocredited. A surgical suite located in the Physiology building is essential for performing 500 surgeries per year on sheep and calves. The surgical suite is adequate to perform aseptic surgery, however, the pens in the recovery room need major repairs since they have peeling paint and are rusting. The floors are wooden slats lying directly on the sealed concrete floor so cleaning feces from between and beneath the slats, while keeping the animals clean and dry, is difficult. The wooden floors cannot be maintained in a sealed condition and so are not impervious to moisture and cannot be cleaned and sanitized adequately. These pens must be replaced to allow adequate sanitation, enhance animal comfort and health, and make cleaning more efficient. Two years ago we began a service to provide investigators with viral and mycoplasmal antibody free rodents. This has been well accepted by our scientists and we have been relatively successful in maintaining VAF colonies of rats and mice. However, we have had ocasional breaks in containment. We do not have the caging equipment to provide cage-to-cage isolation which limits the spread of infectious diseases. We must upgrade to an isolator caging system to give us the required level of quality control needed to maintain disease free rodents. This proposal has the following specific aims. Specific Aim #I: To purchasing stainless steel pens with elevated floors made of vinyl coated expanded metal to replace existing pens in the Physiology building to hold sheep or calves for post surgery recovery and short term post surgical experiments. Specific Aim #2: To purchase Thoren Caging Systems, Inc. positive individually ventilated caging system racks and cages and laminar flow change stations to upgrade our ability for long term housing of viral and mycoplamsal antibody free rodents.

这项动物资源改善提案的目的是让 大学继续向AAALAC认证迈进， 在美国国立卫生研究院最近的两笔翻新赠款的帮助下，进展顺利。 该提案涉及我们计划中的下一个项目， aocredited. 位于生理学大楼的手术室是必不可少的， 每年为绵羊和小牛做500例手术。 手术 套房足以进行无菌手术，然而， 恢复室需要大修，因为他们有剥落的油漆， 生锈了 地板是木板条直接躺在密封的 混凝土地板，以便从板条之间和下面清洁粪便， 同时保持动物的清洁和干燥是很困难的。 木 地板不能保持在密封状态，因此不 不透湿气并且不能充分清洁和消毒。 这些围栏必须更换，以提供足够的卫生条件， 舒适和健康，使清洁更有效。 两年前，我们开始提供一项服务，为调查人员提供病毒和 无支原体抗体的啮齿动物。 这一点得到了我们 科学家和我们已经相对成功地维持VAF 大鼠和小鼠的群体。 不过，我们偶尔会休息一下 安全壳 我们没有笼子设备 笼与笼之间的隔离限制了传染病的传播。 我们必须升级到一个隔离笼系统， 保持啮齿动物无病所需的质量控制水平。 这 该提案有以下具体目标。 具体目标#I：购买带高架地板的不锈钢笔 由乙烯基涂层的金属网制成，以取代现有的钢笔， 用于容纳绵羊或小牛进行术后恢复的生理学建筑 和短期术后实验。 具体目标#2：收购Thoren Caging Systems，Inc.积极 单独通风的笼子系统机架和笼子以及层流 更换站点，以提升我们长期容纳病毒的能力 和无支原体抗体的啮齿动物。