DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

三角研究所（RTI）从事广泛的 使用活体脊椎动物的研究活动。 电流 研究项目包括毒理学，畸形学， 代谢、异生物质的药代动力学、生殖和 生育力（包括化学避孕药的评估），方法 为了更好地输送药物，包括使用可生物降解的聚合物 植入物，以及评估化学品和X射线的诱变效应 对小鼠 这些项目是在一个动物研究机构进行的 1987-1988年进行了翻修，以使其符合 更严格的标准与进行毒理学和 致癌研究 一部分资金（467 995美元）用于翻修 通过发放的PHS赠款（SRC-1 A，1 R24 RR 03776 -01）分配 1987年9月8日，NIH研究资源部。 这些资金被 除了RTI单独资助的2，653，609美元外，RTI也提供了相应的资金。 目的 在这个时候申请额外的资金是为了纠正这些 以前无法弥补的不足。 这些措施包括：1） 翻新笼舍清洗区的地板; 2）添加补充空气 在三个动物房中进行调节，以容纳 需要较低的温度范围; 3）更换18年的笼式洗衣机; （4）购买额外的兔笼。 为这些项目提供资金 将帮助RTI遵守上述建议 AAALAC现场访问报告，并在2010年 根据“实验动物护理和使用指南”，NIH 出版号85-23，1985年修订。

The Research Triangle Institute (RTI) engage in a broad spectrum of research activity involving the use of live vertebrate animals. Current research programs include the studies of toxicology, teratology, metabolism, pharmacokinetics of xenobiotic materials, reproduction and fertility, (including assessment of chemical contraceptive drugs.), methods for better delivery of drugs, including the use of biodegradable polymer implants, and assessment of the mutagenic effects of chemicals and x-rays in mice. These programs are being conducted in an animal research facility that was renovated in 1987-1988 order to bring it into compliance with the more stringent standards associated with conducting toxicological and carcinogenic research. A portion of the funds ($467,995) for renovation were allocated through a PHS grant (SRC-1 A, 1 R24 RR03776-01) issued 9/08/87 by the NIH Division of Research Resources. These funds were matched by RTI in addition to $2,653,609 funded by RTI alone. The purpose of applying for additional funding at this time is to correct those deficiencies that could not be funded previously. These include: 1) refurbishing the floor in the cagewash areas; 2) adding supplemental air conditioning to three animal rooms in order to accommodate rabbits that require a lower temperature range; 3) replacing an 18 year old cagewasher; and 4) purchasing additional rabbit caging. Funding for these projects will help RTI to comply with those recommendations listed in previous AAALAC site visit reports, and to upgrade the husbandry of rabbits in accordance with the "Guide for the Care and Use of Laboratory Animals", NIH Publication No. 85-23, Revised 1985.