DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

三角研究所（RTI）从事广泛的 使用活体脊椎动物的研究活动。 电流 研究项目包括毒理学，畸形学， 代谢、异生物质的药代动力学、生殖和 （包括评估化学品对生育力的影响， 有效避孕药的开发），免疫学， 更好地输送药物，包括使用可生物降解的聚合物 植入物，以及评估化学品和X射线的诱变效应 对小鼠 这些项目是在一个动物研究机构进行的 1987-1088年进行了翻新，以使其符合 更严格的标准与进行毒理学和 致癌研究 RTI由AAALAC认证，必须符合其 的要求以及美国农业部的要求。 此外，RTI还受 PHS“实验室护理和使用指南”中列出的要求 动物”。 此外，RTI在FDA和EPA的指导下进行了大部分动物研究 药物非临床研究质量管理规范（GLP）条例，对以下方面非常严格： 动物环境的控制、监测和记录 study. 目前的动物研究设施于1987-1988年扩建， 包括一个完整的清洁返回走廊系统，并增加10个 动物研究室，总费用为258万美元，其中 47万美元由美国国立卫生研究院提供。 由于预算 由于种种限制，当时无法对整个HVAC系统进行升级。 目前的提议要求提供支助，以升级和扩大现有的 HVAC系统支持条件（温度，特别是湿度） 兔子（对兔子的需求越来越大）， 冗余，以防止丢失有价值的实验，并升级 控制和监测系统，以满足当前的严格要求， 维护和记录环境条件。

The Research Triangle Institute (RTI) engages in a broad spectrum of research activity involving the use of live vertebrate animals. Current research programs include the studies of toxicology, teratology, metabolism, pharmacokinetics of xenobiotic materials, reproduction and fertility, (including assessment of chemical effects on fertility and development of effective contraceptive drugs), immunology, methods for better delivery of drugs, including the use of biodegradable polymer implants, and assessment of the mutagenic effects of chemicals and x-rays in mice. These programs are being conducted in an animal research facility that was renovated in 1987-1088 in order to bring it into compliance with the more stringent standards associated with conducting toxicological and carcinogenic research. RTI is accredited by AAALAC and must meet their requirements as well as those of the USDA. In addition RTI is bound by the requirements listed in the PHS "Guide for the Care and Use of Laboratory Animals". Moreover, RTI conducts most animal studies under FDA and EPA Good Laboratory Practice regulations, which are very stringent regarding control, monitoring and documentation of the environment of animals on study. The current animal research facility was expanded in 1987-1988 to incorporate a complete clean-return corridor system and to add 10 more rooms for animal studies at a total cost of $2.58 million dollars, of which $0.47 million was provided by a grant from NIH. Due to budgetary constraints, the complete HVAC system could not be upgraded at that time. The current proposal requests support to upgrade and expand the present HVAC system to support conditions (temperature and particularly humidity) required for rabbits (for which there is an increasing demand), to provide redundancy to prevent loss of valuable experiments, and to upgrade the control and monitoring system to meet current stringent requirements for maintenance and recording of environmental conditions.