P.E.T. IN OBSESSIVE-COMPULSIVE AND TOURETTE'S DISORDER

这里具体详述的研究项目是PET研究 两种主要的、相关的神经精神疾病，强迫症和TD。这些 疾病不仅彼此有共同的特征，而且 患有其他神经精神性焦虑、情绪和运动障碍。 脑局部葡萄糖代谢的研究将用 氟脱氧葡萄糖(FDG)，而多巴胺和5-羟色胺受体 结合作用将用氟乙基螺酮(FES)进行测量。这个 其具体目的是确定神经解剖学定位。 导致这些基因表达的生化异常 疾病。六组受试者将同时使用FDG和 女性：1.没有强迫症的强迫症(“纯粹强迫症”)，2.有强迫症的强迫症 强迫症，3.无强迫症症状的TD，4.有强迫症症状的TD， 5.伴有慢性多发性抽动(CMT)的TD家系和6.正常对照。 据推测，有纯精神症状的受试者(#1) 会有眼眶回和尾状回异常的FDG和 FES-PET，而单纯运动症状患者(#5)将会异常 只在蛋壳里。受试者组3将有尾状核和 壳核病理，而#2和#4眼眶、尾状核和壳核 异常和将无法区分彼此。这个 收集到的数据也将被检查是否有其他发现。这些 研究不仅将进一步了解 强迫症与TD的病理生理异同 (从而进一步努力控制这些疾病)，但将 也阐明了神经化学解剖学组织 更高的大脑功能。

The research project detailed in specific, herein, is a PET study of two major, related neuropsychiatric diseases, OCD and TD. These diseases share features in common not only with each other, but with other neuropsychiatric anxiety, mood, and movement disorders. Regional cerebral glucose metabolism will be studied with fluorodeoxyglucose (FDG), while dopamine and serotonin receptor binding will be measured with fluoro-ethyl-spiperone (FES). The specific aim is to determine the neuro-anatomical localization of biochemical abnormalities which underlie the expression of these illnesses. Six groups of subject will be studied with both FDG and FES: 1. OCD without compulsions ("pure obsessionals"), 2. OCD with compulsions, 3. TD without OCD symptoms, 4. TD with OCD symptoms, 5. TD relatives with chronic multiple tic (CMT) and 6. normals. It is hypothesized that subjects with purely mental symptoms (#1) will have orbital gyrus and caudate abnormalities on both FDG and FES-PET, while pure motor symptom patients (#5) will be abnormal only in the putamen. Subject group #3 will have caudate and putamen pathology, while #2 and #4 orbital, caudate and putamen abnormalities and will be indistinguishable from each other. The data collected will be inspected for other findings as well. These studies will further understanding not only of the pathophysiological similarities and differences between OCD and TD (and thus further efforts to control these illnesses), but will also shed light on the neuro-chemical-anatomical organization of higher cerebral function.