THE SOLUTION ENVIRONMENT OF NUCLEIC ACIDS
THE SOLUTION ENVIRONMENT OF NUCLEIC ACIDS
批准号:
3071494
负责人:
PETER Jacob ROSSKY
金额:
$5.16万
依托单位国家:
美国
项目类别:
财政年份:
1983
资助国家:
美国
项目状态:
已结题
起止时间:
1983-09-01 至 1988-08-31
中文摘要
解决环境的本质影响,与近因有关
英文摘要
The essential influence of the solution environment, and the proximate
ionic distribution in particular, on nucleic acid biochemistry is widely
acknowledged. Important examples include the formation of the compact
polynucleotide structures of cellular chromatin and binding and recognition
processes in nucleic acid-protein complexes. However, the detailed
microscopic description of this environment is only rudimentary at
present. Therefore, theoretical studies of the distribution of ionic
charge in polynucleotide solutions will be carried out. The first
objective of this research is the description, at the molecular level, of
the spatial distribution of simple salt ions around an extended
polynucleotide chain and an analysis of the dependence of this distribution
on small ion size and charge, as well as polyelectrolyte charge density.
Corresponding studies with simple salt mixtures will be carried out in
order to develop a correspondingly detailed picture of competitive ionic
association. Such studies will provide a much more detailed picture of the
ionic environment of polynucleotides than is presently available from
experimental structural studies, such as those using NMR techniques.
Further, the results will provide tests of the reliability of less
detailed, but also more readily evaluated, theoretical descriptions. The
studies will employ state-of-the-art statistical mechanical methods,
including integral equation and computer simulation techniques; each of
these is a proven approach to the study of simple electrolyte solutions.
The initial polynucleotide model, that of a uniformly charged rod, has been
shown by earlier work to be valuable for the interpretation of experimental
data. Logical refinements of the model to include a more realistic
polyelectrolyte charge distribution, polymer flexibility, and an accurate
treatment of solvent effects will be pursued. The results will elucidate
fundamental aspects of the molecular solution structure which underlie
polynucleotide conformation and polynucleotide interactions with nucleic
acids and polypeptides and will provide necessary elements for the longer
term continued refinement of quantitative models for such interactions.
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会议论文
SOLVATION AND REACTION DYNAMICS OF BIOPOLYMERS
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批准号:2186740
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项目类别:
-
资助金额:$13.58万
-
财政年份:1994
-
负责人:PETER Jacob ROSSKY
-
依托单位:
SOLVATION AND REACTION DYNAMICS OF BIOPOLYMERS
-
批准号:2186741
-
项目类别:
-
资助金额:$14.17万
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财政年份:1994
-
负责人:PETER Jacob ROSSKY
-
依托单位:
SOLVATION AND REACTION DYNAMICS OF BIOPOLYMERS
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批准号:2415192
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项目类别:
-
资助金额:$14.43万
-
财政年份:1994
-
负责人:PETER Jacob ROSSKY
-
依托单位:
SOLVATION AND REACTION DYNAMICS OF BIOPOLYMERS
-
批准号:2186739
-
项目类别:
-
资助金额:$16.05万
-
财政年份:1994
-
负责人:PETER Jacob ROSSKY
-
依托单位:
THE SOLUTION ENVIRONMENT OF NUCLEIC ACIDS
-
批准号:3071493
-
项目类别:
-
资助金额:$5.25万
-
财政年份:1983
-
负责人:PETER Jacob ROSSKY
-
依托单位:
THE SOLUTION ENVIRONMENT OF NUCLEIC ACIDS
-
批准号:3071492
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项目类别:
-
资助金额:$5.24万
-
财政年份:1983
-
负责人:PETER Jacob ROSSKY
-
依托单位:
IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
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批准号:3278219
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项目类别:
-
资助金额:$10.71万
-
财政年份:1982
-
负责人:PETER Jacob ROSSKY
-
依托单位:
IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
-
批准号:3278220
-
项目类别:
-
资助金额:$11.09万
-
财政年份:1982
-
负责人:PETER Jacob ROSSKY
-
依托单位:
IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
-
批准号:3278216
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项目类别:
-
资助金额:$8.19万
-
财政年份:1982
-
负责人:PETER Jacob ROSSKY
-
依托单位:
IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
-
批准号:3278222
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项目类别:
-
资助金额:$12.14万
-
财政年份:1982
-
负责人:PETER Jacob ROSSKY
-
依托单位:
IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
-
批准号:3278221
-
项目类别:
-
资助金额:$11.06万
-
财政年份:1982
-
负责人:PETER Jacob ROSSKY
-
依托单位:
IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
-
批准号:3278218
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项目类别:
-
资助金额:$7.63万
-
财政年份:1982
-
负责人:PETER Jacob ROSSKY
-
依托单位:
IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
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批准号:3278217
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项目类别:
-
资助金额:$7.14万
-
财政年份:1982
-
负责人:PETER Jacob ROSSKY
-
依托单位:
IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
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批准号:3278215
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项目类别:
-
资助金额:$7.16万
-
财政年份:1982
-
负责人:PETER Jacob ROSSKY
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依托单位:
海外基金