IRON DEFICIENCY ANEMIA AND INFANT BEHAVIOR

这项拟议的研究将确定铁剂疗法是否能纠正风湿性肝病。 与铁有关的发育缺陷和行为异常 婴儿期缺乏性贫血。该项目的四个目标是：1) 确定婴儿行为不良的铁耗竭水平 受影响，2)确定注射和注射是否有差异 口服铁剂对行为的影响，3)确定铁剂疗法是否可以 彻底纠正赤字，以及4)确定具体模式 缺铁性贫血儿行为障碍的观察 第一项研究。研究设计为双盲随机对照 儿童行为和发育的短期和长期影响的研究 肌肉内和口服铁剂治疗。200名1至2岁的儿童 将对60例缺铁性贫血、60例缺铁性贫血的婴儿进行研究 血红蛋白值中等的缺乏症患者和80名非贫血患者， 平均分为铁缺乏组和铁充足组。他们的行为 并将使用敏感的量化行为来评估发展 对婴儿智力的测量和全面测试。要确定 缺铁损害婴儿发育的缺铁水平 (目标1)，将在婴儿组中进行治疗前的比较， 其铁状态与参与的生理进程相对应 由于缺铁而变得贫血。完成(目标2)发展 肌注铁意志治疗缺铁婴儿的行为和行为 与之前口服铁剂治疗的类似组进行比较 治疗一周后，三个月后。缺铁婴儿 将实验前后与补铁对照组进行比较 婴儿是否铁质充足决定铁质疗法是否能完全 纠正任何行为缺陷(目标3)。最后，(目标4)这项研究将 证实了我们之前的结果，这些结果展示了一个特定的模式 认知功能受损与异常之间有很强的关系 缺铁性贫血患者的行为和发育测验表现不良 婴儿。这一结果将指导实际的儿科和公共卫生 对预防策略、筛查优先顺序、 需要治疗的铁缺乏症和铁的治疗模式 缺乏性贫血，世界上最常见的营养失调。

The proposed study will determine if iron therapy can correct rhe developmental deficits and behavioral abnormalities associated with iron deficiency anemia in infancey. The four aims of the project are: 1) to determine the level of iron depletion at which infant behavior is adversely affected, 2) to determine if there are differences between injectable and oral iron in behavioral effects, 3) to determine if iron therapy can completely correct the deficits, and 4) to confirm the specific pattern of behavioral disturbances observed in iron deficient anemic infants in our first study. The research design is a double-blind randomized controlled study of the short- and long-term behavioral and developmental effects of intramuscular and oral iron treatment. Two hundred one- to two-year old infants will be studies, 60 with iron deficiency anemia, 60 with iron deficiency with intermediate hemoglobin values, and 80 who are non-anemic, divided equally into iron depleted and iron replete groups. Their behavior and development will be assessed using sensitive quantitative behavior measures as well as overall tests of infant intelligence. To identify the level of iron depletion at which iron deficiency impairs infant development (Aim 1), pretreatment comparisons will be made in the groups of infants, whose iron status corresponds to the physiologic progression involved in becoming anemic from lack of iron. To accomplich (Aim 2,) the development and behavior of iron deficient infants treated with intramuscular iron will be compared to that of similar groups treated with oral iron, before treatment, after one week and after three months. Iron deficient infants will be compared with an iron replete control group before and after all babies become iron replete to determine if iron therapy can completely correct any behavioral deficits (Aim 3). Finally, (Aim 4) the study will confirm our previous results which demonstrated a specific pattern of impaired cognitive functions and a strong relationship between abnormal behavior and poor developmental test performance in iron deficient anemic infants. The results will guide practical pediatric and public health dexisions about preventive strategies, screening priorities, the level of iron deficiency requiring treatment, and the mode of therapy for iron deficiency anemia, the most common nutritional disorder in the world.