PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
批准号:
3076159
负责人:
DAVID S SEGAL
金额:
$5.71万
依托单位国家:
美国
项目类别:
财政年份:
1978
资助国家:
美国
项目状态:
已结题
起止时间:
1978-12-01 至 1988-11-30
中文摘要
本申请描述了一项为期五年的研究计划,
兴奋剂和阿片类药物的精神药理学。 该研究将利用
许多不同的方法,包括行为。药理学上,
神经化学和电生理技术来进一步表征
这些物质的影响,并阐明其潜在的
行动机制。 根据详细的观察,我们发现
一般行为特征或维度(即,固执和
环境参与),区分响应曲线
与不同类型的兴奋剂有关,
物种差异。 我们已经制定了业务定义的措施,
这些行为维度,
研究旨在进一步完善这些措施,并测试我们的
关于潜在的单胺能系统和机制的假说。 的
我们提出的刺激反应的明显普遍特征,
在大鼠中进行研究可能与广泛的刺激作用有关
并涉及这些药剂在治疗
多动儿童
阿片类药物的急性和慢性行为激活作用将被
在大鼠中的特征和阿片受体介导的机制的作用
和单胺系统的基础上的各种响应组件将是
使用各种药理学、神经化学和
离散脑内注射技术。 类似的行为和
机制研究也计划比较和对比激活
推定的σ受体激动剂的作用(例如,SKF-10,047)和PCP,
吗啡样药物(μ受体激动剂)和阿片类药物产生的那些
缩氨酸 此外,还将进行一系列的实验,
研究内源性阿片系统在阿片样反应中的作用
与轻度应激相关的激活。 我们的研究涉及
阿片类药物诱导的刺激导向行为的改变也将被
持续期间内的 阿片类药物诱导的行为激活可能与
麻醉性欣快症和寻求药物的行为,此外,
一个适合各种精神病理学的动物行为模型
其中内源性阿片类药物已经被引入。
英文摘要
This application describes a five-year program of research to study the
psychopharmacology of stimulants and opioids. The research will utilize a
number of different methodologies including behavioral. pharmacological,
neurochemical, and electrophysiological techniques to further characterize
the effects of these substances and to elucidate their underlying
mechanisms of action. Based on detailed observations, we have identified
general behavioral features or dimensions (i.e., perseveration and
environmental engagement) which distinguish the response profiles
associated with different types of stimulants and which appear to transcend
species differences. We have developed operationally defined measures of
these behavioral dimensions that subsume a variety of specific responses
and studies are designed to further refine these measures and to test our
hypotheses regarding underlying monoaminergic systems and mechanisms. The
apparently pervasive characteristics of the stimulant response we propo se
to study in rats may be relevant to the broad ranges of stimulant effects
in humans and to the widespread use of these agents in the treatment of
hyperkinetic children.
The acute and chronic behaviorally activating effects of opioids will be
characterized in rats and the role of opioid receptor mediated mechanisms
and monoamine systems underlying the various response components will be
investigated using a variety of pharmacological, neurochemical, and
discrete intracerebral injection techniques. Similar behavioral and
mechanistic studies are also planned to compare and contrast the activating
effects of putative sigma receptor agonists (e.g., SKF-10,047) and PCP with
those produced by morphine-like agents (mu-receptor agonists) and opioid
peptides. In addition, a series of experiments will be directed at further
examining the role of endogenous opioid systems in the opiate-like response
activation associated with mild stress. Our research concerning
opioid-induced alterations of stimulus-directed behavior will also be
continued. Opioid-induced behavioral activation may be relevant to
narcotic euphoria and drug-seeking behavior and, in addition, may serve as
an appropriate animal behavior model for various forms of psychopathology
in which endogenous opioids have been inplicated.
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会议论文
PSYCHOPHARMACOLOGY OF STIMULANTS
-
批准号:2256510
-
项目类别:
-
资助金额:$9.83万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
-
批准号:3076162
-
项目类别:
-
资助金额:$9.52万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS
-
批准号:2416209
-
项目类别:
-
资助金额:$9.62万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
-
批准号:3076163
-
项目类别:
-
资助金额:$8.15万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
BEHAVIORAL PHARMACOLOGY OF OPIATE-LIKE NEUROPEPTIDES
-
批准号:3207063
-
项目类别:
-
资助金额:$14.32万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
BEHAVIORAL PHARMACOLOGY OF OPIATE-LIKE NEUROPEPTIDES
-
批准号:3207064
-
项目类别:
-
资助金额:$15.63万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS
-
批准号:2256511
-
项目类别:
-
资助金额:$7.4万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
-
批准号:3076158
-
项目类别:
-
资助金额:$5.98万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
-
批准号:3076164
-
项目类别:
-
资助金额:$7.84万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS
-
批准号:2256512
-
项目类别:
-
资助金额:$8.21万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
-
批准号:3076160
-
项目类别:
-
资助金额:$5.82万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
-
批准号:3076161
-
项目类别:
-
资助金额:$5.65万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
BEHAVIORAL PHARMACOLOGY OF OPIATE-LIKE NEUROPEPTIDES
-
批准号:3207061
-
项目类别:
-
资助金额:$9.62万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS
-
批准号:2675727
-
项目类别:
-
资助金额:$9.62万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
-
批准号:3076165
-
项目类别:
-
资助金额:$9.53万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
-
批准号:3076157
-
项目类别:
-
资助金额:$5.99万
-
财政年份:1978
-
负责人:DAVID S SEGAL
-
依托单位:
BEHAVIORAL PHARMACOLOGY OF ACUTE AND CHRONIC AMPHETAMINE
-
批准号:3206959
-
项目类别:
-
资助金额:$28.72万
-
财政年份:1976
-
负责人:DAVID S SEGAL
-
依托单位:
BEHAVIORAL PHARMACOLOGY OF ACUTE AND CHRONIC AMPHETAMINE
-
批准号:3206957
-
项目类别:
-
资助金额:$24.37万
-
财政年份:1976
-
负责人:DAVID S SEGAL
-
依托单位:
BEHAVIORAL PHARMACOLOGY OF ACUTE AND CHRONIC AMPHETAMINE
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批准号:3206955
-
项目类别:
-
资助金额:$16.29万
-
财政年份:1976
-
负责人:DAVID S SEGAL
-
依托单位:
BEHAVIORAL PHARMACOLOGY OF ACUTE AND CHRONIC AMPHETAMINE
-
批准号:3206958
-
项目类别:
-
资助金额:$26.23万
-
财政年份:1976
-
负责人:DAVID S SEGAL
-
依托单位:
海外基金