BEHAVIORAL PHARMACOLOGY OF ACUTE AND CHRONIC AMPHETAMINE
急性和慢性苯丙胺的行为药理学
基本信息
- 批准号:3206957
- 负责人:
- 金额:$ 24.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1976
- 资助国家:美国
- 起止时间:1976-06-29 至 1992-03-31
- 项目状态:已结题
- 来源:
- 关键词:amphetamines behavior disorders behavior test caffeine catecholamines central nervous system stimulants chordate locomotion cocaine dopamine receptor dosage drug abuse experimental brain lesion high performance liquid chromatography laboratory rat methylphenidate neurochemistry neurotoxins neurotransmitter metabolism psychological stressor psychopharmacology
项目摘要
Thorough behavioral characterization of the acute and chronic
amphetamine profiles in experimental animals is a necessary
prerequisite for elucidating the psychological and neurobiological
processes implicated in amphetamine abuse liability and those
affected by various patterns of usage in humans. Several
experimental approaches may facilitate the identification of
specific behaviors that are clinically relevant. In addition to the
use of dosage regimens which simulate various abuse patterns,
comparisons of psychomotor stimulants that produce effects in
humans similar to amphetamine (e.g., cocaine) with those that do
not (e.g., caffeine) may also provide useful behavioral and neuro-
chemical information. Another approach involves the
identification of behavioral dimensions that transcend species-
specific responses. Two such dimensions that are apparent in
virtually all animals given amphetamine-like stimulants are the
perseverative quality of the response and the corresponding
decreases in environmental interaction. Some evidence suggests
that mesostriatal dopamine and serotonin systems may play a role
in perseveration whereas the degree of environmental engagement
may be regulated by a balance in the activities of the dorsal
noradrenergic system and the mesolimbic serotonergic system.
Studies with selective monoamine lesions are designed to test
these hypotheses. Converging evidence indicates that the
appearance of specific components of the behavioral response to
stimulants are intimately related to the experimental conditions,
exhibit strict temporal patterns, and vary dramatically between
animals. However, most biochemical studies have used
pharmacologically, but not necessarily behaviorally relevant
experimental conditions and time points, and have ignored
individual differences in response. More relevant biochemical
data would be obtained in studies of individual animals whose
behavioral profiles have been assessed. In addition, because of
the limitations associated with post-mortem biochemical
analyses, studies are also planned using push-pull perfusion
techniques to measure synaptic transmitter levels in freely
moving animals. This approach provides a continuous measure of
neurotransmitter dynamics throughout the behavioral time course,
and allows each animals to serve as its own control. Our ongoing
and proposed studies represent a multidisciplinary approach aimed
at characterizing the spectrum of stimulant effects produced by
the range of dosage regimens associated with various patterns of
stimulant abuse.
彻底的行为表征的急性和慢性
在实验动物中的安非他明特征是必要的
阐明心理学和神经生物学的先决条件
涉及安非他明滥用倾向的过程以及
受到人类各种使用模式的影响。 几
实验方法可能有助于确定
与临床相关的特定行为。 除了有
使用模拟各种滥用模式的给药方案,
比较产生影响的精神兴奋剂,
类似于安非他明的人类(例如,可卡因)与那些做
不(例如,咖啡因)也可以提供有用的行为和神经-
化学信息 另一种方法涉及
识别超越物种的行为维度-
具体的回答。 两个这样的维度,
事实上,所有被给予安非他明类兴奋剂的动物都是
反应的持续性质量和相应的
减少与环境的相互作用。 一些证据表明
中纹状体多巴胺和血清素系统可能在
而环境参与的程度
可能是由背部活动的平衡来调节的。
去甲肾上腺素能系统和中脑边缘肾上腺素能系统。
选择性单胺损害的研究旨在测试
这些假设。 有证据表明,
行为反应的特定成分的出现,
刺激物与实验条件密切相关,
表现出严格的时间模式,
动物 然而,大多数生物化学研究都使用
但不一定与行为相关
实验条件和时间点,并已忽略
反应的个体差异。 更多相关生化
数据将在个体动物的研究中获得,
已经评估了行为特征。 另外由于
与死后生化检查相关的局限性
分析,研究也计划使用推拉灌注
技术来测量突触递质水平在自由
移动的动物 这种方法提供了一种连续的测量方法,
整个行为时间过程中的神经递质动力学,
并允许每只动物作为自己的对照。 我们正在进行的
拟议的研究代表了一种多学科的方法,
在表征由以下物质产生的刺激效应的光谱方面,
与各种模式相关的剂量方案的范围
兴奋剂滥用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DAVID S SEGAL其他文献
DAVID S SEGAL的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DAVID S SEGAL', 18)}}的其他基金
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
兴奋剂和阿片肽的精神药理学
- 批准号:
3076159 - 财政年份:1978
- 资助金额:
$ 24.37万 - 项目类别:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
兴奋剂和阿片肽的精神药理学
- 批准号:
3076162 - 财政年份:1978
- 资助金额:
$ 24.37万 - 项目类别:
BEHAVIORAL PHARMACOLOGY OF OPIATE-LIKE NEUROPEPTIDES
阿片样神经肽的行为药理学
- 批准号:
3207063 - 财政年份:1978
- 资助金额:
$ 24.37万 - 项目类别:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
兴奋剂和阿片肽的精神药理学
- 批准号:
3076163 - 财政年份:1978
- 资助金额:
$ 24.37万 - 项目类别:
BEHAVIORAL PHARMACOLOGY OF OPIATE-LIKE NEUROPEPTIDES
阿片样神经肽的行为药理学
- 批准号:
3207064 - 财政年份:1978
- 资助金额:
$ 24.37万 - 项目类别:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
兴奋剂和阿片肽的精神药理学
- 批准号:
3076158 - 财政年份:1978
- 资助金额:
$ 24.37万 - 项目类别:
PSYCHOPHARMACOLOGY OF STIMULANTS AND OPIOID PEPTIDES
兴奋剂和阿片肽的精神药理学
- 批准号:
3076164 - 财政年份:1978
- 资助金额:
$ 24.37万 - 项目类别:
相似海外基金
Developing a Technology-based Staff Training Tool for an Empirically-Supported Positive Preventive Intervention For Supporting Children At-Risk for the Development of Disruptive Behavior Disorders
开发基于技术的员工培训工具,以进行实证支持的积极预防干预,以支持面临破坏性行为障碍风险的儿童
- 批准号:
10380982 - 财政年份:2021
- 资助金额:
$ 24.37万 - 项目类别:
Neural mechanism of stress-related feeding behavior disorders
应激相关进食行为障碍的神经机制
- 批准号:
18K09529 - 财政年份:2018
- 资助金额:
$ 24.37万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Disruptive Behavior Disorders in Children after Severe TBI: Family and Neighborhood Context
严重创伤性脑损伤后儿童的破坏性行为障碍:家庭和邻里环境
- 批准号:
9223010 - 财政年份:2017
- 资助金额:
$ 24.37万 - 项目类别:
Emotional-behavior disorders in South African children affected by AIDS
受艾滋病影响的南非儿童的情绪行为障碍
- 批准号:
8204766 - 财政年份:2010
- 资助金额:
$ 24.37万 - 项目类别:
Emotional-behavior disorders in South African children affected by AIDS
受艾滋病影响的南非儿童的情绪行为障碍
- 批准号:
7836665 - 财政年份:2010
- 资助金额:
$ 24.37万 - 项目类别:
Emotional-behavior disorders in South African children affected by AIDS
受艾滋病影响的南非儿童的情绪行为障碍
- 批准号:
8052882 - 财政年份:2010
- 资助金额:
$ 24.37万 - 项目类别:
Online Parent Training for Children with Behavior Disorders
针对行为障碍儿童的在线家长培训
- 批准号:
8507687 - 财政年份:2009
- 资助金额:
$ 24.37万 - 项目类别:
Online Parent Training for Children with Behavior Disorders
针对行为障碍儿童的在线家长培训
- 批准号:
7671719 - 财政年份:2009
- 资助金额:
$ 24.37万 - 项目类别:
A Family Affair: Parent Management of Children's Disruptive Behavior Disorders
家庭事务:家长对儿童破坏性行为障碍的管理
- 批准号:
8013548 - 财政年份:2009
- 资助金额:
$ 24.37万 - 项目类别:
Online Parent Training for Children with Behavior Disorders
针对行为障碍儿童的在线家长培训
- 批准号:
8397056 - 财政年份:2009
- 资助金额:
$ 24.37万 - 项目类别: