NEURAL CONTROL OF THE CIRCULATION IN PREGNANCY

妊娠期循环的神经控制

• 批准号: 3074558
• 负责人: Cheryl M Heesch
• 金额: $ 6.57万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3074558
• 关键词: baroreceptors; environmental adaptation; heart rate; hemodynamics; laboratory rat; neurotransmitters; pregnancy circulation; reflex; vascular resistance

My immediate career plan is to continue the work outlined in this proposal on neural control of the circulation in pregnancy and to firmly establish an independent laboratory. Very little research has been performed in which cardiovascular reflex mechanisms have been examined in pregnancy, and completion of this project will help me establish my independence. The overall goal of the proposal is to test the, general hypothesis that during pregnancy adaptations occur in the neural control of the circulation at the level of the baroreceptors, the central nervous system and the peripheral vasculature which contribute to the hemodynamic profile characteristic of normal pregnancy. These adaptations could be related to the changes in blood volume, prostanoid production, and/or changes in the interaction between reflex systems. Experiments are planned in three groups of rats - nonpregnant, midterm-pregnant (progesterone dominant), and late-pregnant (estrogen dominant) - and comparisons will be made to determine the effects of pregnancy on: 1) single unit afferent arterial baroreceptor discharge; 2) arterial and cardiopulmonary baroreflex control of efferent regional sympathetic nerve activity; 3) parasympathetic and sympathetic components of reflex control of heart rate; 4) barorereflex control of uterine vascular resistance and efferent sympathetic nerve activity to the uterus; and 5) efferent responses to activation of cardiovascular related central nervous system sites. My long-term goal over the next five years is to become knowledgeable in concepts and techniques that will allow me to examine mechanisms for central nervous system adaptations in control of sympathetic outflow and cardiovascular function at a more cellular level. The environment at The Ohio State University is excellent in this regard. The Department of Physiology has several faculty members with international reputations in neurophysiology whose laboratories I would like to work in on a faculty internship, the University has an active interdisciplinary neuroscience group which focuses on autonomic control mechanisms, and the Ohio State Biotechnology Center Faculty offers hands-on workshops for training in techniques used in molecular biology. The normal teaching and service obligations at The Ohio State University preclude my participation in the training options mentioned to an extent that will significantly enhance my research. If I received a Research Career Development Award, the University would release me from a substantial portion of non-research related activities (teaching and service) and would support my plan to obtain further training both at Ohio State University and at another University.

我近期的职业计划是继续从事这份报告中概述的工作。 关于神经控制的循环在怀孕和坚定的建议 建立独立的实验室。 很少有研究已经 进行了心血管反射机制的检查， 怀孕，这个项目的完成将帮助我建立我的 独立 该提案的总体目标是测试，一般 假设在怀孕期间适应发生在神经控制 压力感受器水平的循环，中枢神经 系统和外周血管系统，有助于血液动力学 正常妊娠的特征。 这些适应可能是 与血容量、前列腺素产生和/或 反射系统之间相互作用的变化。 实验 计划在三组大鼠中进行-未妊娠、中期妊娠 （孕激素占主导地位）和晚期妊娠（雌激素占主导地位）-和 将进行比较，以确定妊娠对以下方面的影响：1） 单一单位传入动脉压力感受器放电; 2）动脉和 传出区域交感神经的心肺压力反射控制 活动; 3）反射控制的副交感神经和交感神经成分 压力反射控制子宫血管阻力， 向子宫传出交感神经活动;以及5）传出交感神经活动 对心血管相关中枢神经系统激活的反应 网站. 我未来五年的长期目标是成为 在概念和技术方面的知识，使我能够检查 中枢神经系统适应机制的控制 交感神经流出和心血管功能在更多的细胞水平。 在这方面，俄亥俄州州立大学的环境非常好。 生理学系有几名教员， 在神经生理学方面享有国际声誉， 我喜欢在教师实习工作，大学有一个积极的 一个跨学科的神经科学小组，专注于自主控制 机制，和俄亥俄州州立生物技术中心教师提供 为培训分子生物学技术而举办的实践讲习班。 在俄亥俄州州立大学的正常教学和服务义务 在一定程度上排除了我参加上述培训的可能性 这将极大地促进我的研究。 如果我收到一份研究报告， 职业发展奖，大学将释放我从一个 大部分与研究无关的活动（教学和 服务），并将支持我的计划，以获得进一步的培训， 俄亥俄州州立大学和另一所大学。