NEURAL CONTROL OF THE CIRCULATION IN PREGNANCY

我近期的职业计划是继续这份工作 关于孕期血液循环神经调控的建议 建立一个独立的实验室。几乎没有什么研究是 已对心血管反射机制进行了检查 怀孕，并完成这个项目将帮助我建立我的 独立。这项提案的总体目标是测试，一般 怀孕期间适应发生在神经控制中的假设 在压力感受器水平上的循环，中枢神经 有助于血流动力学的系统和外周血管系统 正常妊娠的特征。这些适应可能是 与血容量、前列腺素分泌和/或 反射系统之间相互作用的变化。实验是 计划在三组大鼠中-未怀孕，中期-怀孕 (黄体酮占优势)和晚孕(雌激素占优势)--以及 将进行比较以确定怀孕对以下方面的影响：1) 单一单位传入动脉压力感受器放电；2)动脉和 心肺压力反射对传出区域交感神经的控制 活动；3)反射控制的副交感和交感成分 4)压力反射控制子宫血管阻力和 子宫的传出交感神经活动；5)传出 心血管相关中枢神经系统激活的反应 网站。我在未来五年的长期目标是成为 精通概念和技术，使我能够研究 中枢神经系统适应机制在控制精神分裂症中的作用 交感神经流出和更多细胞水平的心血管功能。 在这方面，俄亥俄州立大学的环境非常好。 生理学系有几名教职员工 在神经生理学方面的国际声誉，我会选择他们的实验室 喜欢在教职员工实习，大学里有一个积极的 专注于自主控制的跨学科神经科学小组 机制，俄亥俄州立生物技术中心教职员工提供 用于分子生物学技术培训的动手讲习班。 俄亥俄州立大学的正常教学和服务义务 在一定程度上排除了我参加上述培训方案的可能性 这将大大加强我的研究。如果我收到一份研究报告 职业发展奖，大学会把我从 很大一部分非研究相关活动(教学和 服务)，并将支持我的计划，以获得进一步的培训在 俄亥俄州立大学和另一所大学。

My immediate career plan is to continue the work outlined in this proposal on neural control of the circulation in pregnancy and to firmly establish an independent laboratory. Very little research has been performed in which cardiovascular reflex mechanisms have been examined in pregnancy, and completion of this project will help me establish my independence. The overall goal of the proposal is to test the, general hypothesis that during pregnancy adaptations occur in the neural control of the circulation at the level of the baroreceptors, the central nervous system and the peripheral vasculature which contribute to the hemodynamic profile characteristic of normal pregnancy. These adaptations could be related to the changes in blood volume, prostanoid production, and/or changes in the interaction between reflex systems. Experiments are planned in three groups of rats - nonpregnant, midterm-pregnant (progesterone dominant), and late-pregnant (estrogen dominant) - and comparisons will be made to determine the effects of pregnancy on: 1) single unit afferent arterial baroreceptor discharge; 2) arterial and cardiopulmonary baroreflex control of efferent regional sympathetic nerve activity; 3) parasympathetic and sympathetic components of reflex control of heart rate; 4) barorereflex control of uterine vascular resistance and efferent sympathetic nerve activity to the uterus; and 5) efferent responses to activation of cardiovascular related central nervous system sites. My long-term goal over the next five years is to become knowledgeable in concepts and techniques that will allow me to examine mechanisms for central nervous system adaptations in control of sympathetic outflow and cardiovascular function at a more cellular level. The environment at The Ohio State University is excellent in this regard. The Department of Physiology has several faculty members with international reputations in neurophysiology whose laboratories I would like to work in on a faculty internship, the University has an active interdisciplinary neuroscience group which focuses on autonomic control mechanisms, and the Ohio State Biotechnology Center Faculty offers hands-on workshops for training in techniques used in molecular biology. The normal teaching and service obligations at The Ohio State University preclude my participation in the training options mentioned to an extent that will significantly enhance my research. If I received a Research Career Development Award, the University would release me from a substantial portion of non-research related activities (teaching and service) and would support my plan to obtain further training both at Ohio State University and at another University.