OPIOID ANALGESICS: PHARMACOLOGICAL AND BEHAVIORAL FACTOR

这项研究科学家奖的目的是释放博士。 戴克斯特拉的大部分行政和教学 这样她就可以把时间花在研究上 专注于阿片类镇痛药的项目。 特别强调 将被放置在可能提供有效疼痛的化合物上 缓解，但减少依赖的可能性。 这些包括 丁丙诺啡、选定的κ激动剂和几种混合激动剂- 对手。 镇痛作用将在松鼠中进行检查 猴休克滴定法和啮齿动物热 歧视程序。 为了比较，其他几种行为 将对终点进行检查，包括时间表对照、复杂 条件歧视和药物歧视行为。 在 所有这些调查，重点将放在 阿片受体激动剂的行为效应与 推测对μ和κ阿片受体类型具有活性。 为了 为了绘制这些效应之间的关系，将进行比较， 基于1）不同的行为特征和效力 各种阿片类激动剂之间的关系2） 阿片类拮抗剂减弱这些激动剂的作用和3） 它们之间存在交叉耐受性。

The objective of this Research Scientist Award is to free Dr. Dykstra of the majority of her administrative and teaching responsibilities so that she can devote her time to a research program focused on the opioid analgesics. In particular emphasis will be placed on compounds which may provide effective pain relief, but with reduced dependence potential. These include buprenorphine, selected kappa agonists and several mixed agonist- antagonists. Analgesic effects will be examined in the squirrel monkey shock titration procedure and in rodent thermal discrimination procedure. For comparison, several other behavioral endpoints will be examined, including schedule-controlled, complex conditional discriminations and drug discrimination behavior. In all of these investigations, emphasis will be placed on the relationship between the behavioral effects of opioid agonists and presumed activity at mu and kappa opioid receptor types. In order to draw relationships between these effects, comparisons will be made on the basis of 1) differing behavioral profiles and potency relationships amongst various opioid agonists 2) the potency of opioid antagonists in attenuating effects of these agonists and 3) the occurrence of cross tolerance between them.