MATERNAL-FETAL HEMODYNAMICS RESPONSES TO EXERCISE

母胎血流动力学对运动的反应

• 批准号: 3078027
• 负责人: SEONAE YEO
• 金额: $ 6.8万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1996-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3078027
• 关键词: blood pressure; cardiac output; embryo /fetus; exercise; female; heart rate; hemodynamics; human subject; intracardiac volume; pregnancy circulation

The growing participation by women in the workforce and physical fitness has mandated a focused study of exercise during pregnancy. Currently, the scientific literature is limited in delineating clear and specific exercise guidelines for promoting maternal health while minimizing fetal risk. The existing exercise guidelines for pregnant women are equivocal at best and perhaps without scientific basis. The focus of the proposed program is to examine maternal and fetal hemodynamic repercussions of medically accepted levels of acute, non- weight-bearing exercise. The primary objective of this three-year program is to advance the candidate's knowledge and research skills in the area of exercise and pregnancy, by intensive training and extensive mentorship. The major aims of the proposed study are: 1) To assess longitudinally the maternal-fetal hemodynamic repercussions during exercise; 2) to define the relationships among exercise intensity, uterine artery blood flow change, and umbilical artery blood flow change, while monitoring fetal safety; and 3) to assess the safety limits of exercise throughout gestation, according to the indices of maternal heart rate and Rating of Perceived Exertion. This experimental study will employ a repeated-measures design with a sample of healthy, non-smoking, pregnant volunteers (n=45). Maternal heart rate, RPE, cardiac output, stroke volume, arterial pressure, uterine artery blood flow, and umbilical artery blood flow will be measured at different gestation periods and exercise intensities. The exercise tests will be conducted with a discontinuous, symptom-limited protocol. The study will ultimately aide development of unequivocal exercise guidelines for healthy pregnant women, while strengthening the candidate's career in this area.

妇女越来越多地参与劳动力和身体健康