INSULIN SENSITIVITY IN NATIVE HAWAIIANS WITH NIDDM

患有 NIDDM 的夏威夷原住民的胰岛素敏感性

• 批准号: 3080941
• 负责人: Richard Arakaki
• 金额: $ 8.7万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-24 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3080941
• 关键词: Hawaiian; adipocytes; autoantibody; blood chemistry; glucose metabolism; human population genetics; human subject; insulin receptor; insulin sensitivity /resistance; lipolysis; noninsulin dependent diabetes mellitus; phosphorylation; receptor binding; tissue /cell culture

Native Hawaiians have a high prevalence rate of DM which impacts greatly on the morbidity and mortality of this minority population. Peripheral cell resistance to insulin is one of the features that characterize NIDDM. This study proposes to investigate the in vitro insulin sensitivity of subcutaneous adipocytes from native Hawaiians with and without NIDDM. Furthermore, with the predominance of genetic admixture within this population, we wish to examine the contribution of genetic inheritance to the possible in vitro cellular defects in diabetic native Hawaiians. Subjects will be interviewed and enrolled through the Queen Emma Clinic of Queens Medical Center, a University of Hawaii Medical School affiliated hospital, where approximately 2000 native Hawaiians, 200 with NIDDM receive health care. Processing of blood and adipocyte samples, hormonal measurements, and experiments of cellular insulin sensitivity will be performed in a laboratory of the Department of Medicine located in a building adjacent to the hospital.

夏威夷原住民的糖尿病患病率很高，这对 这一少数民族人口的发病率和死亡率。外周细胞 胰岛素抵抗是NIDDM的特征之一。这 这项研究建议研究人血清白蛋白的体外胰岛素敏感性 患有和不患有NIDDM的夏威夷本地人的皮下脂肪细胞。 此外，由于遗传混合体在这一领域的优势 我们希望研究遗传对人类的贡献 夏威夷原住民糖尿病患者可能存在的体外细胞缺陷。 受试者将通过艾玛女王诊所进行面试和登记 皇后区医学中心，夏威夷大学附属医学院 医院，大约2000名夏威夷原住民，200名患有NIDDM的人在这里接受治疗 医疗保健。荷尔蒙血液和脂肪细胞样本的处理 细胞胰岛素敏感性的测量和实验将是 在医学系的实验室进行，位于 医院旁边的大楼。