患有 NIDDM 的夏威夷原住民的胰岛素敏感性-猫眼课题宝

患有 NIDDM 的夏威夷原住民的胰岛素敏感性

批准号：

3080939

负责人：

Richard Arakaki

金额：

$7.56万

依托单位：

UNIVERSITY OF HAWAII AT MANOA

依托单位国家：

美国

项目类别：

财政年份：

1990

资助国家：

美国

项目状态：

已结题

起止时间：

1990-09-24 至 1995-08-31

来源：

https://reporter.nih.gov/project-details/3080939

关键词：

Hawaiian adipocytes autoantibody blood chemistry glucose metabolism human population genetics human subject insulin receptor insulin sensitivity /resistance lipolysis noninsulin dependent diabetes mellitus phosphorylation receptor binding tissue /cell culture

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英文摘要

Native Hawaiians have a high prevalence rate of DM which impacts greatly on the morbidity and mortality of this minority population. Peripheral cell resistance to insulin is one of the features that characterize NIDDM. This study proposes to investigate the in vitro insulin sensitivity of subcutaneous adipocytes from native Hawaiians with and without NIDDM. Furthermore, with the predominance of genetic admixture within this population, we wish to examine the contribution of genetic inheritance to the possible in vitro cellular defects in diabetic native Hawaiians. Subjects will be interviewed and enrolled through the Queen Emma Clinic of Queens Medical Center, a University of Hawaii Medical School affiliated hospital, where approximately 2000 native Hawaiians, 200 with NIDDM receive health care. Processing of blood and adipocyte samples, hormonal measurements, and experiments of cellular insulin sensitivity will be performed in a laboratory of the Department of Medicine located in a building adjacent to the hospital.

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