PEPTIDE HORMONE STIMULATED INOSITOL METABOLISM

这项赠款计划资助詹姆斯·艾伦·沙曼博士的临床 由奥布里博士和莫里森博士赞助的研究者奖。 索罗·克拉赫 Shayman博士在巴恩斯接受博士后培训 医院和华盛顿大学医学院内科和 肾脏科 在过去两年中进行的初步研究 研究了缓激肽诱导的 肾细胞培养物中的多磷酸肌醇代谢。 这些观察结果 将被扩展到研究磷脂酰的更具体的方面， 肌醇循环，因为它适用于远端肾小管上皮细胞。 具体来说，锂，环AMP以及其他激素的作用， 影响因素有待研究。 这项工作将作为一种工具， 在肾内科获得更密集的生物医学研究培训 华盛顿大学药理学系。

This grant proposes to fund Dr. James Alan Shayman for a Clinical Investigator Award under the sponsorship of Dr. Aubrey Morrison and Dr. Saulo Klahr. Dr. Shayman has received his post-doctoral training at Barnes Hospital and Washington University Medical School in Internal Medicine and Nephrology. Initial studies performed during the last two years of this training have investigated Bradykinin-induced changes in polyphosphoinositide metabolism in renal cell culture. These observations are to be extended to investigate more specific aspects of the phosphatidyl inositol cycle as it applies to distal renal tubular epithelia. Specifically, the roles of lithium, cyclic AMP, as well as other hormonal effectors are to be studied. This work will serve as a vehicle toward gaining more intensive biomedical research training within the Renal Division and Department of Pharmacology at Washington University.