PEPTIDE HORMONE STIMULATED INOSITOL METABOLISM

肽激素刺激肌醇代谢

• 批准号: 3080617
• 负责人: JAMES ALAN SHAYMAN
• 金额: $ 6.86万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3080617
• 关键词: bradykinin; cyclic AMP; inositol; kidney cell; lithium; peptide hormone metabolism; tissue /cell culture

This grant proposes to fund Dr. James Alan Shayman for a Clinical Investigator Award under the sponsorship of Dr. Aubrey Morrison and Dr. Saulo Klahr. Dr. Shayman has received his post-doctoral training at Barnes Hospital and Washington University Medical School in Internal Medicine and Nephrology. Initial studies performed during the last two years of this training have investigated Bradykinin-induced changes in polyphosphoinositide metabolism in renal cell culture. These observations are to be extended to investigate more specific aspects of the phosphatidyl inositol cycle as it applies to distal renal tubular epithelia. Specifically, the roles of lithium, cyclic AMP, as well as other hormonal effectors are to be studied. This work will serve as a vehicle toward gaining more intensive biomedical research training within the Renal Division and Department of Pharmacology at Washington University.

这笔拨款旨在资助詹姆斯·艾伦·谢尔曼博士进行临床研究