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SYNTHESIS OF CONGENERS AND PRO DRUGS

SYNTHESIS OF CONGENERS AND PRO DRUGS
同系物和前体药物的合成
批准号：
3610181
负责人：
DAVID C BAKER
金额：
$12.92万
依托单位：
UNIVERSITY OF ALABAMA IN TUSCALOOSA
依托单位国家：
美国
项目类别：
财政年份：
1982
资助国家：
美国
项目状态：
已结题
起止时间：
1982-09-30 至 1986-03-31
来源：
https://reporter.nih.gov/project-details/3610181
关键词：
chemical reaction chemical structure drug design /synthesis /production heterocyclic compounds lead physical property

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中文摘要
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英文摘要
The Drug Synthesis and Chemistry Branch (DS&CB) of the Developmental Therapeutics Program (DTP) of the Division of Cancer Treatment (DCT) of the National Cancer Institute (NCI) is seeking contractors with chemical synthesis expertise to synthesis a variety of compounds for evaluation as potential anticancer agents. The objectives of this project are to: synthesize congeners of synthetic compounds with confirmed activity; design and synthesize "pro-drugs" and other compounds that possess elements of both congener and pro-drug; and synthesize compounds related to products of natural origin and other related heterocycles.
期刊论文(2)
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会议论文
Substrate properties of analogs of myo-inositol.
肌醇类似物的底物特性。
DOI： --
发表时间： 1988
期刊： Molecular pharmacology
影响因子： 3.6
作者： [Moyer,JD, Reizes,O, Ahir,S, Jiang,C, Malinowski,N, Baker,DC]
通讯作者： Baker,DC
Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).
吡嗪重氮基钠盐 (NSC-361456) 的合成、化学稳定性和临床前抗肿瘤活性。
DOI： --
发表时间： 1987
期刊： Anti-cancer drug design
影响因子： --
作者： [Baker,DC, Hand,ES, Plowman,J, Rampal,JB, Safavy,A, Haugwitz,RD, Narayanan,VL]
通讯作者： Narayanan,VL
SYNTHESIS OF CONGENERS AND PRODRUGS
SYNTHESIS OF CONGENERS AND PRODRUGS
SYNTHESIS OF CONGENERS AND PRODRUGS
SYNTHESIS OF CONGENERS AND PRODRUGS
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