COMPARATIVE ONCOLOGY RESEARCH PROGRAM

其目的是定义和使用狗身上自然发生的肿瘤作为 人类实验性癌症治疗的模型。狗的寿命 足够长，以至于晚期肿瘤和正常组织的反应可以 已评估。这是一项利用资源的机构间研究，网址为 科罗拉多州立大学，杜克大学医学中心，北卡罗来纳州 州立大学和亚利桑那大学。本程序基于 实验外科、医学、放射和热疗。这个 热疗项目被设计成与人类热疗接口 杜克大学医学中心的项目。协作将继续与 亚利桑那大学的热疗项目直接通过 该计划的生物统计和数据管理部分。细胞学和 将对肿瘤进行组织学分类，这可能有助于选择 用于早期研究的合适的人类患者群体。肿瘤 将接受在此之前接受过有限治疗干预的患者 加入协议，并且有合理的可能性 为了控制。科罗拉多州立大学动物肿瘤中心和 北卡罗来纳州动物癌症治疗计划将为动物提供 这些研究的患者。项目1在这方面提供了支持 这个项目。项目2是一项全身热疗的研究。 黑色素瘤。犬类黑色素瘤患者将被送往兽医 科罗拉多州立大学和北卡罗来纳州立大学的医院 大学。这些动物将被分配到这项研究中，该研究结合了 热疗、放疗和化疗，试图改善两者 局部控制和转移性疾病控制。项目3是一项关于 淋巴瘤的全身热疗和化疗。这也将是 需要动物肿瘤中心的资源。项目4是一项关于 肢体保留术，包括手术、放疗和化疗 骨肉瘤。项目5是对流式细胞仪技术的研究，以 辅助分析组织样本，作为潜在的预测分析 肿瘤对治疗的反应。将有可能获得肿瘤组织 治疗前后和最终与肿瘤有关 对随后的治疗反应的特征。

The objectives are to define and use naturally occurring tumors in dogs as models for experimental cancer therapy for humans. The life span of dogs is sufficiently long so that late tumor and normal tissue response can be evaluated. This is an inter-institutional study utilizing resources at Colorado State University, Duke University Medical Center, North Carolina State University and the University of Arizona. This program is based on experimental surgery, medicine, radiation and hyperthermia. The hyperthermia projects are designed to interface with the human hyperthermia program at Duke University Medical Center. Collaboration is continued with the hyperthermia program at the University of Arizona directly through the biostatistics and data management portions of the program. Cytometric and histologic classification of tumors will be done which may aid in selection of appropriate human patient populations for early phase studies. Tumors will be treated which have had limited therapeutic intervention prior to entry into the protocols and for which there is a reasonable probability for control. The Animal Tumor Center at Coloardo State University and the North Carolina Animal Cancer Treatment Program will provide the animal patients for these studies. Project 1 provides support for that aspect of the program. Project 2 is a study of whole body hyperthermia for melanomas. Canine melanoma patients will be admitted at veterinary hospitals at Colorado State University and North Carolina State University. Those animals will be assigned to this study which combines hyperthermia, irradiation and chemotherapy in an attempt to improve both local control and control of metastatic disease. Project 3 is a study of whole body hyperthermia and chemotherapy for lymphomas. This will also require the resources of the animal tumor centers. Project 4 is a study of limb sparing techniques, including surgery, radiation and chemotherapy for osteogenic sarcomas. Project 5 is a study of flow cytometric techniques to aid in analysis of tissue samples as potentially predictive assays for response of tumors to therapy. It will be possible to obtain tumor tissues prior to and following treatment and ultimately to relate tumor characteristics to subsequent response to therapy.