COMPARATIVE ONCOLOGY RESEARCH PROGRAM

目的是定义和使用犬中自然发生的肿瘤， 用于人类实验性癌症治疗的模型。 狗的寿命 以使晚期肿瘤和正常组织反应可以 评估。 这是一项机构间研究， 科罗拉多州立大学、杜克大学医学中心、北卡罗来纳州 州立大学和亚利桑那大学。 本程序是基于 实验性手术、医学、放射和热疗。 的 热疗项目旨在与人体热疗 杜克大学医学中心的一个项目。 继续与 亚利桑那大学的热疗项目直接通过 生物统计学和数据管理部分的程序。 细胞计数和 将进行肿瘤的组织学分类，这可能有助于选择 用于早期研究的适当人类患者群体。 肿瘤 将接受有限治疗干预的患者， 进入协议，并且有合理的可能性 为了控制 科罗拉多州立大学的动物肿瘤中心和 北卡罗来纳州动物癌症治疗计划将提供动物 这些研究的患者。 项目1为以下方面提供支持： 节目 项目2是一项全身热疗研究， 黑素瘤。 犬黑色素瘤患者将在兽医 科罗拉多州立大学和北卡罗来纳州的医院 大学 这些动物将被分配到本研究中， 热疗、放疗和化疗，试图改善这两种情况 局部控制和转移性疾病的控制。 项目三是研究 全身热疗和化疗治疗淋巴瘤。 这也将 需要动物肿瘤中心的资源。 项目4是一项研究 保肢技术，包括手术、放疗和化疗， 成骨肉瘤 项目5是一项流式细胞技术的研究， 有助于分析组织样品，作为潜在的预测测定， 肿瘤对治疗的反应。 将有可能获得肿瘤组织 在治疗之前和之后，并最终与肿瘤相关 对后续治疗反应的特征。

The objectives are to define and use naturally occurring tumors in dogs as models for experimental cancer therapy for humans. The life span of dogs is sufficiently long so that late tumor and normal tissue response can be evaluated. This is an inter-institutional study utilizing resources at Colorado State University, Duke University Medical Center, North Carolina State University and the University of Arizona. This program is based on experimental surgery, medicine, radiation and hyperthermia. The hyperthermia projects are designed to interface with the human hyperthermia program at Duke University Medical Center. Collaboration is continued with the hyperthermia program at the University of Arizona directly through the biostatistics and data management portions of the program. Cytometric and histologic classification of tumors will be done which may aid in selection of appropriate human patient populations for early phase studies. Tumors will be treated which have had limited therapeutic intervention prior to entry into the protocols and for which there is a reasonable probability for control. The Animal Tumor Center at Coloardo State University and the North Carolina Animal Cancer Treatment Program will provide the animal patients for these studies. Project 1 provides support for that aspect of the program. Project 2 is a study of whole body hyperthermia for melanomas. Canine melanoma patients will be admitted at veterinary hospitals at Colorado State University and North Carolina State University. Those animals will be assigned to this study which combines hyperthermia, irradiation and chemotherapy in an attempt to improve both local control and control of metastatic disease. Project 3 is a study of whole body hyperthermia and chemotherapy for lymphomas. This will also require the resources of the animal tumor centers. Project 4 is a study of limb sparing techniques, including surgery, radiation and chemotherapy for osteogenic sarcomas. Project 5 is a study of flow cytometric techniques to aid in analysis of tissue samples as potentially predictive assays for response of tumors to therapy. It will be possible to obtain tumor tissues prior to and following treatment and ultimately to relate tumor characteristics to subsequent response to therapy.