COMPARATIVE ONCOLOGY RESEARCH PROGRAM

该计划的目标是定义和使用自然发生的 作为人类实验性癌症治疗的模型。 的 这些动物的寿命足够长， 可以评估反应和肿瘤控制。 这是一个跨机构的 利用科罗拉多州兽医学院资源的研究 和北卡罗来纳州州立大学，以及位于 达特茅斯和杜克大学。 该计划是基于实验 医学、热疗、放射和手术。 细胞计数和组织学 将进行动物癌症的分类，这可能有助于选择 用于早期研究的适当人类患者群体。 癌症 将在入组前接受有限的治疗干预 协议中，并有一个合理的概率， 控制 科罗拉多州立大学动物肿瘤中心和 北卡罗来纳州动物癌症治疗计划将提供动物癌症 这些研究的患者（核心组分A）。 项目一是研究 全身热疗和化疗治疗淋巴瘤。 犬淋巴瘤 病人将被送往科罗拉多州的兽医医院， 北卡罗来纳州。 项目2将评估 顺铂在犬同种异体骨移植术后局部控制的实验研究 骨肉瘤 本发明的目的是提供一种肢体保留手术， 局部控制概率高。 项目3是对WBH的研究， 照射对脑和犬脑肿瘤反应。 末 将评价脑肿瘤床的反应以及局部控制 脑肿瘤 该计划的长期目标是更快的应用和接受 人类医学中新的癌症治疗模式。 宠物实验 动物癌症可以提供治疗增益的指示， 并可用于指导 人体临床试验 该计划的总体目标是 评估可能改善癌症控制的新治疗方法， 毒性极小。

The objectives of this program are to define and use naturally occurring tumors in pets as models for experimental cancer therapy for humans. The life span of these animals is sufficiently long so that late normal tissue response and tumor control can be evaluated. This is an interinstitutional study utilizing resources of veterinary colleges at Colorado State University and North Carolina State University, and cancer centers at Dartmouth and Duke University. This program is based on experimental medicine, hyperthermia, radiation, and surgery. Cytometric and histologic classification of animal cancers will be done which may aid in selection of appropriate human patient populations for early phase studies. Cancers will be treated which have limited therapeutic intervention prior to entry into the protocols and for which there is a reasonable probability for control. The Animal Tumor Center at Colorado State University and the North Carolina Animal Cancer Treatment Program will provide animal cancer patients for these studies (Core Component A). Project 1 is a study of whole body hyperthermia and chemotherapy for lymphomas. Canine lymphoma patients will admitted at the veterinary hospitals at Colorado State and North Carolina State. Project 2 will evaluate the local release of cisplatin at the site of allograft replacement for local control of canine osteosarcomas. The objective is to provide a limb sparing procedure with a high probability for local control. Project 3 is a study of WBH and irradiation for response of brain and canine brain tumors. The late response of the brain tumor bed will be evaluated as well as local control of brain tumors. The long term goal of this program is more rapid application and acceptance of new cancer treatment modalities in human medicine. Experiments with pet animal cancers can provide indications of therapeutic gain much more rapidly than can be done in humans and can be use to provide direction for human clinical trials. The overall objective of this program is to evaluate new therapeutic approaches which may improve cancer control with minimal toxicity.