PRECLINICAL AND CLINICAL CANCER RESEARCH: HYPERTHERMIA

临床前和临床癌症研究：热疗

• 批准号: 3093306
• 负责人: J. ROBERT STEWART
• 金额: $ 95.79万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-04-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3093306
• 关键词: hyperthermia therapy; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; physical chemical interaction; radiation sensitivity

The research proposed is a broadly based Program Project based on proved strengths in engineering and physics, biology, and clinical research in hyperthermia. Seven interrelated and interdependent research projects and a supporting Core are requested with the overall objective to study hyperthermia in a systematic fashion in order to further define its role in clinical care of patients with cancer. The research is focused on the following objectives. l. To explore certain biological effects of hyperthermia (alone or with S-irradiation and selected drugs which have potential clinical application) through studies designed: a) to explain basic mechanisms, b) to provide background information in animal models for future clinical application, and c) to provide preliminary clinical data through Phase I and II pilot studies. 2. To explore improved methods of hyperthermia (equipment, treatment techniques, thermometry, and treatment planning) as applied to investigational hyperthermia treatment of patients with cancer. 3. To participate in quality assurance programs as they become available and selected Phase III clinical trials sponsored by national cooperative groups.

所提出的研究是一个基础广泛的项目，基于Proven 在工程和物理、生物学和临床研究方面的优势 体温过高。七个相互关联和相互依存的研究项目和 需要一个支持核心，总体目标是研究 体温过高的系统性研究，以便进一步明确其在 癌症患者的临床护理。这项研究的重点是 遵循以下目标。 L。探讨高温(单独或联合)的某些生物学效应 S--辐射与临床潜在应用药物的选择) 通过设计的研究：a)解释基本机制，b)提供 未来临床应用的动物模型的背景信息， 和c)通过第一阶段和第二阶段试点提供初步临床数据 学习。 2.探索改进的热疗方法(设备、治疗 技术、测温和治疗计划)应用于 癌症患者的研究性热疗。 3.在有质量保证计划时参与这些计划 和由国家合作社赞助的精选III期临床试验 组。