PRECLINICAL AND CLINICAL CANCER RESEARCH: HYPERTHERMIA

临床前和临床癌症研究：热疗

• 批准号: 3093307
• 负责人: J. ROBERT STEWART
• 金额: $ 78.94万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-04-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3093307
• 关键词: hyperthermia therapy; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; physical chemical interaction; radiation sensitivity

The research proposed is a broadly based Program Project based on proved strengths in engineering and physics, biology, and clinical research in hyperthermia. Seven interrelated and interdependent research projects and a supporting Core are requested with the overall objective to study hyperthermia in a systematic fashion in order to further define its role in clinical care of patients with cancer. The research is focused on the following objectives. l. To explore certain biological effects of hyperthermia (alone or with S-irradiation and selected drugs which have potential clinical application) through studies designed: a) to explain basic mechanisms, b) to provide background information in animal models for future clinical application, and c) to provide preliminary clinical data through Phase I and II pilot studies. 2. To explore improved methods of hyperthermia (equipment, treatment techniques, thermometry, and treatment planning) as applied to investigational hyperthermia treatment of patients with cancer. 3. To participate in quality assurance programs as they become available and selected Phase III clinical trials sponsored by national cooperative groups.

建议的研究是一个基础广泛的计划项目的基础上证明 在工程和物理学，生物学和临床研究方面的优势， 体温过高 七个相互关联和相互依存的研究项目， 需要一个支持核心，其总体目标是研究 为了进一步确定其在以下方面的作用， 癌症患者的临床护理。 研究的重点是 以下目标。 L.探讨高温（单独或与 S-辐射和具有潜在临床应用的选定药物） 通过研究：a）解释基本机制，B）提供 背景技术在用于未来临床应用的动物模型中， 以及c）通过第一和第二阶段试验提供初步临床数据 问题研究 2.探讨改进的热疗方法（设备、治疗 技术、测温和治疗计划）， 癌症患者的研究性热疗。 3.参与质量保证计划，因为他们变得可用 以及由国家合作组织赞助的部分III期临床试验 组

项目成果

Past clinical studies and future directions.

过去的临床研究和未来的方向。

• 发表时间: 1984
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Stewart,JR

Immunophenotypic characterization of canine lymphoproliferative disorders.

犬淋巴增殖性疾病的免疫表型特征。

• 发表时间: 1997
• 期刊: In vivo (Athens, Greece)
• 作者: Ruslander,DA;Gebhard,DH;Tompkins,MB;Grindem,CB;Page,RL
• 通讯作者: Page,RL

Computer-aided design of two-dimensional electric-type hyperthermia applicators using the finite-difference time-domain method.

时域有限差分法计算机辅助二维电动热疗头设计。

• DOI: 10.1109/10.83606
• 发表时间: 1991
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Shaw,JA;Durney,CH;Christensen,DA
• 通讯作者: Christensen,DA

Abdominal regional hyperthermia with an annular phased array.

使用环形相控阵进行腹部区域热疗。

• DOI: 10.1200/jco.1986.4.5.775
• 发表时间: 1986
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: Sapozink,MD;GibbsJr,FA;Egger,MJ;Stewart,JR
• 通讯作者: Stewart,JR

DNA damage production in CHO cells at elevated temperatures.

CHO 细胞在高温下产生 DNA 损伤。

• DOI: 10.1002/jcp.1041240318
• 发表时间: 1985
• 期刊: Journal of cellular physiology
• 影响因子: 5.6
• 作者: Warters,RL;Brizgys,LM;Axtell-Bartlett,J
• 通讯作者: Axtell-Bartlett,J