PRECLINICAL AND CLINICAL CANCER RESEARCH: HYPERTHERMIA

临床前和临床癌症研究：热疗

• 批准号: 3093301
• 负责人: J. ROBERT STEWART
• 金额: $ 88.07万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-04-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3093301
• 关键词: hyperthermia therapy; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; physical chemical interaction; radiation sensitivity

The research proposed is a broadly based Program Project based on proved strengths in engineering and physics, biology, and clinical research in hyperthermia. Seven interrelated and interdependent research projects and a supporting Core are requested with the overall objective to study hyperthermia in a systematic fashion in order to further define its role in clinical care of patients with cancer. The research is focused on the following objectives. l. To explore certain biological effects of hyperthermia (alone or with S-irradiation and selected drugs which have potential clinical application) through studies designed: a) to explain basic mechanisms, b) to provide background information in animal models for future clinical application, and c) to provide preliminary clinical data through Phase I and II pilot studies. 2. To explore improved methods of hyperthermia (equipment, treatment techniques, thermometry, and treatment planning) as applied to investigational hyperthermia treatment of patients with cancer. 3. To participate in quality assurance programs as they become available and selected Phase III clinical trials sponsored by national cooperative groups.

拟议的研究是一个基础广泛的计划项目，基于已证明的 工程和物理、生物学和临床研究方面的优势 高热。 七个相互关联和相互依赖的研究项目和 需要一个支持核心，以实现学习的总体目标 以系统的方式进行热疗，以进一步明确其在 癌症患者的临床护理。 该研究的重点是 以下目标。 湖探索热疗的某些生物学效应（单独或与 S射线照射及筛选具有临床应用潜力的药物） 通过设计的研究：a）解释基本机制，b）提供 动物模型的背景信息以供未来临床应用， c) 通过I期和II期试点提供初步临床数据 研究。 2.探索改进的热疗方法（设备、治疗方法） 技术、测温和治疗计划）应用于 癌症患者的研究性热疗治疗。 3. 参与可用的质量保证计划 并选定国家合作社赞助的III期临床试验 组。