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AUTOLOGOUS MARROW TRANSPLANTATION FOR PATIENTS WITH MALIGNANT LYMPHOMA

AUTOLOGOUS MARROW TRANSPLANTATION FOR PATIENTS WITH MALIGNANT LYMPHOMA
恶性淋巴瘤患者的自体骨髓移植
批准号：
3817223
负责人：
FREDERICK APPLEBAUM
金额：
$0.0万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3817223
关键词：
Hodgkin's disease autologous transplantation bone marrow transplantation busulfan cyclophosphamide dosage homologous transplantation human subject human therapy evaluation lymphoma neoplasm /cancer chemotherapy neoplasm /cancer radiation therapy neoplasm /cancer therapy remission /regression

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中文摘要
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英文摘要
High dose chemotherapy or chemoradiotherapy followed by autologous marrow transplantation (AMT) can cure some patients of malignant lymphoma who are otherwise unlikely to be cured. In this project we propose to (1) define the curability of patients with various categories of malignant lymphoma transplanted at first relapse or second remission using a preparative regimen of CY and 12 Gy TBI; (2) compare the outcomes of syngeneic, allogeneic and autologous transplantation; (3) explore the use of AMT early in the disease course of patients with poor prognostic factors; (4) evaluate new preparative regimens in patients with lymphoma in resistant relapse and (5) measure the utility of GM-CSF posttransplant.
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