MONOCLONAL ANTIBODIES TO HUMAN FACTOR RECEPTORS

人类因子受体单克隆抗体

• 批准号: 3807260
• 负责人: GORDON H SATO
• 金额: --
• 依托单位: ADIRONDACK BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3807260
• 关键词: antireceptor antibody; cell growth regulation; epidermal growth factor; growth factor; growth factor receptors; growth media; human tissue; hybridomas; insulin receptor; lymphocyte; monoclonal antibody; neoplastic cell; neoplastic growth; peptide hormone; tissue /cell culture; transferrin receptor

We propose to generate human monoclonal antibodies to cell surface receptors of known functional importance by immunizing normal human peripheral blood cells in vitro under serum-free culture conditions. These antibodies will be examined for their effects on the growth of human tumor cells bearing the appropriate receptors. The methodologies that will be developed will significantly reduce the current problems involved in obtaining suitably immunized human lymphocytes and will make human monoclonal antibodies with useful specificities more accessible to the scientific community.

我们建议产生人单克隆抗体细胞表面 通过免疫正常人， 在无血清培养条件下体外培养外周血细胞。 这些 将检测抗体对人类肿瘤生长的影响 携带适当受体的细胞。 将采用的方法 发展将大大减少目前的问题， 获得适当免疫的人淋巴细胞， 具有有用特异性的单克隆抗体， 科学界。