MICROBIAL ECOLOGY & ITS RELATION TO DENTAL DISEASE

微生物生态学

• 批准号: 3094917
• 负责人: RONALD JOHN GIBBONS
• 金额: $ 48.49万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-09-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3094917
• 关键词: host organism interaction; human subject; oral bacteria; oral health; periodontium disorder

This proposal presents a broad program whose goal is to provide key pieces of basic information required to better understand the etiology and pathogenesis of dental caries and various forms of periodontal disease, and to formulate rational approaches for their control. The program integrates the efforts of investigators experienced in the areas of microbiology, animal experimentation, electron microscopy, nutrition, periodontology and clinical dentistry, and represents an extension of on-going studies. The specific aims include attempts to develop and refine methodology for studying important oral bacteria, and studies of the properties of odontopathic bacteria which account for, or influence their virulence. Other aims relate to elucidating parameters which influence the transmission and acquisition of prominent oral bacteria. Special emphasis is being devoted to studies of host and environmental factors which affect the colonization of potentially- important odontopathic bacteria. Included are studies of the influence of dietary components, topically-applied fluorides, polymorphonuclear leucocytes and their products, certain antibodies, intraoral location, and fibronectin on oral microbial colonization.

该提案提出了一项广泛的计划，其目标是提供 更好地理解所需的关键基本信息 龋齿和各种形式龋齿的病因和发病机制 牙周病，并制定合理的治疗方法 他们的控制。 该计划整合了研究人​​员的努力 在微生物学、动物实验领域经验丰富， 电子显微镜、营养学、牙周病学和临床 牙科，代表了正在进行的研究的延伸。 这 具体目标包括尝试开发和完善方法 用于研究重要的口腔细菌及其特性 解释或影响其牙病细菌 毒力。 其他目标涉及阐明参数，这些参数 影响显着口语的传播和习得 细菌。 特别强调的是对宿主和 影响定植的环境因素 潜在重要的牙病细菌。 包括有 研究饮食成分的影响，局部应用 氟化物、多形核白细胞及其产物， 某些抗体、口腔内位置和口腔上的纤连蛋白 微生物定植。