MICROBIAL ECOLOGY AND ITS RELATION TO DENTAL DISEASES

微生物生态学及其与牙科疾病的关系

• 批准号: 3094914
• 负责人: RONALD JOHN GIBBONS
• 金额: $ 45.96万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-09-01 至 1987-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3094914
• 关键词: dental disorder; host organism interaction; human subject; oral bacteria

This proposal presents a broad program whose goal is to provide key pieces of basic information required to better understand the etiology and pathogenesis of dental caries and various forms of periodontal disease, and to formulate rational approaches for their control. The program integrates the efforts of investigators experienced in the areas of microbiology, animal experimentation, electron microscopy, nutrition, periodontology and clinical dentistry, and represents an extension of on-going studies. The specific aims include attempts to develop and refine methodology for studying important oral bacteria, and studies of the properties of odontopathic bacteria which account for, or influence their virulence. Other aims relate to elucidating parameters which influence the transmission and acquisition of prominent oral bacteria. Special emphasis is being devoted to studies of host and environmental factors which affect the colonization of potentially- important odontopathic bacteria. Included are studies of the influence of dietary components, topically-applied fluorides, polymorphonuclear leucocytes and their products, certain antibodies, intraoral location, and fibronectin on oral microbial colonization.

该提案提出了一个广泛的计划，其目标是提供关键部分