MICROBIAL ECOLOGY AND ITS RELATION TO DENTAL DISEASES

该提案提出了一个广泛的计划，其目标是提供关键的部分， 所需的基本信息，以更好地了解病因和 龋齿和各种形式的牙周病的发病机制，以及 制定合理的控制方法。 该方案整合了 在微生物学领域经验丰富的研究人员的努力， 动物实验，电子显微镜，营养学，牙周病学和 临床牙科，并代表了正在进行的研究的延伸。 的 具体目标包括努力制定和完善方法， 研究重要的口腔细菌，并研究 牙齿致病菌，占，或影响其毒力。 其他目的涉及阐明影响生物学特性的参数。 传播和获得突出的口腔细菌。 特别强调 正在致力于研究影响人类健康的宿主和环境因素， 潜在重要的牙齿致病菌的定植。 包括 是研究饮食成分的影响，局部应用 氟化物、多形核白细胞及其产物、某些 抗体、口内定位和纤连蛋白对口腔微生物的影响 殖民化

This proposal presents a broad program whose goal is to provide key pieces of basic information required to better understand the etiology and pathogenesis of dental caries and various forms of periodontal disease, and to formulate rational approaches for their control. The program integrates the efforts of investigators experienced in the areas of microbiology, animal experimentation, electron microscopy, nutrition, periodontology and clinical dentistry, and represents an extension of on-going studies. The specific aims include attempts to develop and refine methodology for studying important oral bacteria, and studies of the properties of odontopathic bacteria which account for, or influence their virulence. Other aims relate to elucidating parameters which influence the transmission and acquisition of prominent oral bacteria. Special emphasis is being devoted to studies of host and environmental factors which affect the colonization of potentially- important odontopathic bacteria. Included are studies of the influence of dietary components, topically-applied fluorides, polymorphonuclear leucocytes and their products, certain antibodies, intraoral location, and fibronectin on oral microbial colonization.