MICROBIAL ECOLOGY AND ITS RELATION TO DENTAL DISEASES

微生物生态学及其与牙科疾病的关系

• 批准号: 3094916
• 负责人: RONALD JOHN GIBBONS
• 金额: $ 72.06万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-09-01 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3094916
• 关键词: dental disorder; host organism interaction; human subject; oral bacteria

This proposal presents a broad program whose goal is to provide key pieces of basic information required to better understand the etiology and pathogenesis of dental caries and various forms of periodontal disease, and to formulate rational approaches for their control. The program integrates the efforts of investigators experienced in the areas of microbiology, animal experimentation, electron microscopy, nutrition, periodontology and clinical dentistry, and represents an extension of on-going studies. The specific aims include attempts to develop and refine methodology for studying important oral bacteria, and studies of the properties of odontopathic bacteria which account for, or influence their virulence. Other aims relate to elucidating parameters which influence the transmission and acquisition of prominent oral bacteria. Special emphasis is being devoted to studies of host and environmental factors which affect the colonization of potentially- important odontopathic bacteria. Included are studies of the influence of dietary components, topically-applied fluorides, polymorphonuclear leucocytes and their products, certain antibodies, intraoral location, and fibronectin on oral microbial colonization.

该提案提出了一个广泛的计划，其目标是提供关键部分 更好地了解病因所需的基本信息 龋齿和各种形式的牙周病的发病机制，以及 制定合理的控制方法。 该程序集成了 在微生物学领域经验丰富的研究人员的努力， 动物实验、电子显微镜、营养学、牙周病学和 临床牙科，代表了正在进行的研究的延伸。 这 具体目标包括尝试开发和完善方法 研究重要的口腔细菌，并研究其特性 解释或影响其毒力的牙病细菌。 其他目标涉及阐明影响影响的参数 重要口腔细菌的传播和获得。 特别强调 致力于研究影响宿主和环境因素 潜在重要的牙病细菌的定殖。 包括 是对饮食成分影响的研究，局部应用 氟化物、多形核白细胞及其产物，某些 抗体、口腔内定位和纤连蛋白对口腔微生物的影响 殖民化。