GASTROINTESTINAL FUNCTION--REGULATION AND ADAPTATION

请求提供支持，以调查《公约》的监管和适应 胃肠功能。请求为六个项目提供支助，其中三个 科学核心和行政核心，所有这些都将受益 从项目人员的互动和由 这些核心。项目1将研究食物在肠道中的作用。 胃肠适应的调节与生长和 功能。这将在正常胃发育的模型中进行研究， 肠切除和旁路手术与特定营养素的呈递 直击我的内心。项目2将描述在 肠道平滑肌在适应过程中的变化及可能的判定 负责的机制。Smooth的物理和生化特性 肠道搭桥术后将对肌肉进行研究，并与变化相关 既有局部因素，也有系统性因素。项目3将在动态中进行检查 不同肠道区域的内在推进能力如何 发展并适应切除、旁路、梗阻和去神经。 项目4将使用离子选择电极和膜片钳 洞察K+和Na+进入和调节的技术 穿过上皮细胞。项目5将探索这些机制 通过胆汁酸诱导结肠的活跃分泌，利用 发现新生儿的结肠中不存在这种诱导 兔子。项目6将采用各种生理系统和 免疫学技术来检验这一假设快速、免疫 对旋毛虫的排斥是一种适应性反应，通过 小肠上皮的生理性改变。这些 项目将得到三个科学核心的支持：(A)动物外科 和维护，(B)形态，(C)计算和管理 核心(D)概述的研究在性质上是基本的；然而，信息 派生将适用于各种正常功能和临床 条件。这些因素包括胃肠道发育，以及 胃肠道的饮食成分，因改变而引起的腹泻 在运动和运输过程中，溃疡和条件，如短期 肠道综合征、肠梗阻和寄生虫。

Support is requested to investigate the regulation and adaptation of gastrointestinal function. Support is requested for six projects, three scientific cores, and an administrative core, all of which will benefit from the interactions of the project personnel and the support provided by the cores. Project 1 will examine the role of food in the gut in the regulation of gastrointestinal adaptation as related to growth and function. This will be studied in models of normal gastric development, intestinal resection and by-pass and the presentation of specific nutrients to the gut. Project 2 will describe the changes that take place in intestinal smooth muscle during adaptation and determine possible mechanisms responsible. The physical and biochemical properties of smooth muscle will be studied following intestinal bypass and related to changes in both local and systemic factors. Project 3 will examine in dynamic terms how the intrinsic propulsive ability of various intestinal regions develops and adapts to resection, by-pass, obstruction and denervation. Project 4 will make use of ion-selective electrodes and patch-clamp techniques to gain insight into the regulation of K+ and Na+ entrance and exit across epithelial cells. Project 5 will explore the mechanisms whereby bile acids induce active secretion in the colon, taking advantage of the finding that this induction is absent from the colon of the newborn rabbit. Project 6 will employ a variety of physiological systems and immunological techniques to test the hypothesis that rapid, immune rejection of T. spiralis is an adaptive response effected through physiological alterations in the small intestinal epithelium. These projects will be supported by three scientific cores: (A) Animal Surgery and Maintenance, (B) Morphology, (C) Computational and an administrative core (D) The studies outlined are basic in nature; however, the information derived will be applicable to a variety of normal functions and clinical conditions. These include gastrointestinal development, and the effects of dietary constituents on the G.I. tract, diarrhea resulting from alterations in motility and transport processes, ulcers, and conditions such as short bowel syndrome, intestinal obstruction, and parasitism.