GASTROINTESTINAL FUNCTION--REGULATION AND ADAPTATION

要求提供支助，以调查 胃肠功能 请求支助六个项目， 科学核心和行政核心，所有这些都将受益于 从项目人员的互动和提供的支持， 核心。 项目1将研究食物在肠道中的作用， 调节与生长相关的胃肠适应， 功能 这将在正常胃发育的模型中进行研究， 肠切除术和旁路以及特定营养素的提供 打到肚子上 项目2将描述发生在 肠平滑肌在适应和确定可能的 机制负责。 光滑的物理和生化特性 肌肉将在肠旁路手术后进行研究， 无论是局部因素还是系统因素。 项目3将在动态中检查 说明肠道各区域的内在推进能力 发展并适应切除、旁路、阻塞和去神经支配。 项目4将利用离子选择性电极和膜片钳技术 技术，以了解调节K+和Na+入口， 穿过上皮细胞 项目5将探讨机制 由此胆汁酸诱导结肠中的主动分泌， 新生儿的结肠中没有这种诱导， 兔子 项目6将采用各种生理系统， 免疫学技术来检验快速免疫 拒绝T。spiralis是一种适应性反应， 小肠上皮的生理变化。 这些 项目将由三个科学核心支持：（A）动物外科 和维护，（B）形态学，（C）计算和管理 （D）概述的研究是基本性质的;然而， 推导出的将适用于各种正常功能和临床 条件 这些包括胃肠道发育，以及 胃肠道的饮食成分肠道，由改变引起的腹泻 在运动和运输过程中，溃疡和诸如短 肠综合征肠梗阻和寄生虫病

Support is requested to investigate the regulation and adaptation of gastrointestinal function. Support is requested for six projects, three scientific cores, and an administrative core, all of which will benefit from the interactions of the project personnel and the support provided by the cores. Project 1 will examine the role of food in the gut in the regulation of gastrointestinal adaptation as related to growth and function. This will be studied in models of normal gastric development, intestinal resection and by-pass and the presentation of specific nutrients to the gut. Project 2 will describe the changes that take place in intestinal smooth muscle during adaptation and determine possible mechanisms responsible. The physical and biochemical properties of smooth muscle will be studied following intestinal bypass and related to changes in both local and systemic factors. Project 3 will examine in dynamic terms how the intrinsic propulsive ability of various intestinal regions develops and adapts to resection, by-pass, obstruction and denervation. Project 4 will make use of ion-selective electrodes and patch-clamp techniques to gain insight into the regulation of K+ and Na+ entrance and exit across epithelial cells. Project 5 will explore the mechanisms whereby bile acids induce active secretion in the colon, taking advantage of the finding that this induction is absent from the colon of the newborn rabbit. Project 6 will employ a variety of physiological systems and immunological techniques to test the hypothesis that rapid, immune rejection of T. spiralis is an adaptive response effected through physiological alterations in the small intestinal epithelium. These projects will be supported by three scientific cores: (A) Animal Surgery and Maintenance, (B) Morphology, (C) Computational and an administrative core (D) The studies outlined are basic in nature; however, the information derived will be applicable to a variety of normal functions and clinical conditions. These include gastrointestinal development, and the effects of dietary constituents on the G.I. tract, diarrhea resulting from alterations in motility and transport processes, ulcers, and conditions such as short bowel syndrome, intestinal obstruction, and parasitism.