General Clinical Research Center

全科临床研究中心

• 批准号: 6956739
• 负责人: STANLEY G SCHULTZ
• 金额: $ 55.18万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-04 至 2006-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6956739
• 关键词: clinical research; human subject

EXCEED THE SPACE PROVIDED. The University of Texas Health Science Center at Houston (UTHSC-H) requests continued support for the operation of the University Clinical Research Center (UCRC) at Memorial Hermann Hospital (MHH). The UTHSC - H is located in the Texas Medical Center (TMC), the largest Medical Center in the World. In operation since 1984, the UCRC continues to grow and be utilized by a wide diversity of investigators from the UTHSC - Medical School and 8 other institutions in the TMC. In 2003, projects from the MDAnderson Cancer Center, the Texas Heart Institute andthe UTHSC- H School of Nursing, School of Public Health, the Brown Institute for Molecular Medicine, Dental Branch, Mental Sciences Institute and the Graduate School of Biological Sciences represented 16% of our protocols and utilized 26% of our ancillaries' budget. When compared to our previous competitive renewal, we have increased the number of visits by 75%, and doubled the number of approved protocols and publications. With the support of MHH, a new UCRC with twice the capacity will be operational in the winter of 2004. Continued funding will enable us to conduct novel studies to understand and treat aortic aneurysms, neonatal hyperbilirubinemia, Ewing's sarcoma, infectious diarrhea due to enteroaggregative E. coli, diabetes in children and their families, autoimmune disorders such as scleroderma, and clinically significant obesity, among other clinical research projects that are ongoing or planned. Support is also requested to a) Continue the operations of our genotyping and sequencing core laboratory at the UCRC, b) Support a cooperative effort of the 5 GCRCs in Texas to conduct off site clinical research in the Lower Rio Grande Valley (LRGV) in South Texas. This facility will host regional projects developed by local investigators in the LRGV region as well as for new and existingprojects from all GCRCs in Texas and in the future other GCRCs located out of Texas. This model will allow ei'fective utilization of resources and provide access to patient oriented clinical research for a traditionallyunderserved Hispanic population with health access disparities c) Continue the Clinical Research Feasibility Funds program, and d) Continue the UTHSC - H UCRC Mentored Medical Student Research Program.

超出空间 但前提是。 德克萨斯大学休斯顿健康科学中心(UTHSC-H)请求继续支持 赫尔曼纪念医院大学临床研究中心(UCRC)的运作。这个 UTHSC-H位于德克萨斯医疗中心(TMC)，这是世界上最大的医疗中心。在……里面 自1984年运营以来，城市资源中心不断发展壮大，并被来自世界各地的各种调查人员利用。 UTHSC-医学院和TMC的其他8个机构。2003年，来自MDAnderson的项目 癌症中心，德克萨斯心脏研究所和UTHSC-H护理学院，公共卫生学院， 布朗分子医学研究所，牙科，精神科学研究所和研究生院 生物科学部代表了我们方案的16%，并利用了我们附属机构预算的26%。什么时候 与我们之前的竞争续订相比，我们的访问次数增加了75%，翻了一番 经批准的议定书和出版物的数量。在MHH的支持下，新的UCRC具有两倍的 运力将于2004年冬季投入使用。继续提供资金将使我们能够进行新的研究 认识和治疗主动脉瘤、新生儿高胆红素血症、尤文肉瘤、感染性腹泻 由于肠道聚集性大肠杆菌，儿童及其家庭的糖尿病，自身免疫性疾病，如 硬皮病和临床显著肥胖，以及正在进行或正在进行的其他临床研究项目 有计划的。还需要支持以a)继续我们的基因分型和测序核心的操作 UCRC的实验室，b)支持德克萨斯州5个GCRC的合作努力，以进行异地临床 在南得克萨斯州格兰德河谷(LRGV)的研究。该设施将主办地区性项目 由LRGV地区的当地调查人员以及所有GCRC的新项目和现有项目开发 在德克萨斯州，以及未来其他位于德克萨斯州以外的GCRC。这种模式将允许EI有效地利用 资源并为传统上服务不足的西班牙裔提供以患者为导向的临床研究 C)继续实施临床研究可行性基金计划，以及 D)继续UTHSC-H UCRC指导医学生研究计划。

项目成果

Adverse pregnancy outcomes in women with systemic lupus erythematosus from a multiethnic US cohort: LUMINA (LVI) [corrected].

• 发表时间: 2008-03
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: R. Andrade;Martha L. Sanchez;G. Alarcón;B. Fessler;Mónica;Fernández;A. Bertoli;M. Apte;L. Vilá;A. M. Arango;J. Reveille

Universal primer applications for pyrosequencing.

用于焦磷酸测序的通用引物应用。

• DOI: 10.1385/1-59745-377-3:57
• 发表时间: 2007
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Guo,Dong-Chuan;Milewicz,DiannaM
• 通讯作者: Milewicz,DiannaM

Pilot study of Flt3 ligand comparing intraperitoneal with subcutaneous routes on hematologic and immunologic responses in patients with peritoneal carcinomatosis and mesotheliomas.

Flt3 配体初步研究，比较腹膜内和皮下途径对腹膜癌病和间皮瘤患者血液学和免疫学反应的影响。

• 发表时间: 2003
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research.
• 作者: Freedman,RalphS;Vadhan-Raj,Saroj;Butts,Cherie;Savary,Cherylyn;Melichar,Bohuslav;Verschraegen,Claire;Kavanagh,JohnJ;Hicks,MarshallE;Levy,LawrenceB;Folloder,JodyK;Garcia,MichaelE
• 通讯作者: Garcia,MichaelE

Molecular epidemiology of the fsr locus and of gelatinase production among different subsets of Enterococcus faecalis isolates.

粪肠球菌分离株不同亚群中 fsr 位点和明胶酶产生的分子流行病学。

• DOI: 10.1128/jcm.42.5.2317-2320.2004
• 发表时间: 2004
• 期刊: Journal of clinical microbiology
• 影响因子: 9.4
• 作者: Roberts,JillC;Singh,KavindraV;Okhuysen,PabloC;Murray,BarbaraE
• 通讯作者: Murray,BarbaraE

Growth hormone improves protein catabolism and growth in prepubertal children with HIV infection.

生长激素可改善青春期前感染艾滋病毒儿童的蛋白质分解代谢和生长。

• DOI: 10.1111/j.1365-2265.2005.02331.x
• 发表时间: 2005
• 期刊: Clinical endocrinology.
• 作者: Hardin,DanaS;Rice,Julie;Doyle,MarilynE;Pavia,Andrew
• 通讯作者: Pavia,Andrew