THE BIOLOGY OF SICKLE CELL DISEASE

镰状细胞病的生物学

• 批准号: 3098168
• 负责人: EUGENE GOLDWASSER
• 金额: $ 94.49万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3098168
• 关键词: X ray crystallography; X ray microscopy; computer assisted sequence analysis; computer graphics /printing; cryopreservation; hemoglobin Ss; hemoprotein biosynthesis; hemoprotein structure; histochemistry /cytochemistry; image processing; molecular dynamics; molecular pathology; polymers; protein sequence; respiratory oxygenation; reticulocytes; sickle cell anemia; stainings

A group of several independent scientists at The University of Chicago seeks to create a coordinated program in sickle cell disease research. Their approaches vary widely, but they share a common interest: the erythrocyte in health and disease, sickle cell disease in particular. Their aims are to draw closer together around the topic of sickle cell disease; to create a highly interactive scientific group whose diverse interests will be synergistic; to foster new and better research, both individual and collaborative; and to expedite such research through coordinated sharing of scientific information, instrumentation, core facilities, patients, and data. The benefits of the program project will be the promotion of mutual education, new scientific insights, improved collaboration, and increased efficiency and economy of research through a central focus on sickle cell disease. This application seeks support for this program. The theme of this program is the biology of the erythrocyte in sickle cell disease. In that the research emanates from independent scientific programs, it is not unitary but diverse and complementary. The program thus draws strength from the breadth of its membership and a wide range of expertise. There is, nevertheless, considerable continuity in the scope of the research. Huttenlocher seeks to relieve the occlusive cerebral vascular disease arising from the compromised rheology of sickled cells. Shen proposes to elucidate the structural basis for the irreversibly-sickled cell; an altered sub-membrane filamentous network. Josephs will continue his characterization of hemoglobin S fibers by high resolution electron microscopy. Potel will apply computer techniques to the analysis of Josephs's EM data and Huttenlocher's positron emission tomographs. Steck will test a novel hypothesis which explains and promises to reverse the increased passive permeability of sickle cell membranes to small solutes. Goldwasser will study the expression of globin genes and Gross will study the control of their translation. Not all projects interact with all others; this would be an unrealistic goal for research programs that originate with investigators rather than with a single organizer. There is, however, a stong element of mutual interest that is bound to help advance the science in each subproject.

芝加哥大学的几位独立科学家组成的小组 旨在建立一个镰状细胞病研究的协调计划。 他们的方法差异很大，但他们有一个共同的利益： 红细胞在健康和疾病中的作用，特别是镰状细胞病。 他们的目的是围绕镰状细胞病的话题拉近距离， 疾病;创建一个高度互动的科学小组， 利益将是协同的;促进新的和更好的研究， 个人和合作;并通过以下方式加快这种研究 协调共享科学信息、仪器、核心 设施、患者和数据。 该项目的好处将 促进相互教育，新的科学见解，提高 合作，并通过提高研究的效率和经济性， 主要关注镰状细胞病。 本申请寻求支持 这个戒酒会这 这个节目的主题是红细胞的生物学 镰状细胞病。 因为这项研究来自于独立的 科学计划，它不是单一的，而是多样性和互补性。 的 因此，该计划从其成员的广泛性和广泛的参与中汲取力量 专业知识的范围。 然而，在这方面有相当大的连续性。 研究的范围。 Huttenlocher试图缓解闭塞的 镰状动脉血流动力学受损引起的脑血管病 细胞 沈教授提出， 不可逆的镰状细胞;改变的亚膜丝状网络。 约瑟夫斯将继续他的血红蛋白S纤维的表征， 分辨电子显微镜 波特尔将运用计算机技术， Josephs电磁数据和Huttenlocher正电子发射分析 断层摄影 Steck将测试一个新的假设，该假设解释并承诺 逆转镰状细胞膜的被动渗透性增加， 小溶质 Goldwasser将研究珠蛋白基因的表达， 格罗斯将研究如何控制他们的翻译。 并非所有项目 与所有其他人互动;这将是一个不切实际的研究目标 这些计划是由调查人员发起的，而不是由一个 主办方 然而，有一个共同利益的重要因素， 一定会帮助推进每个子项目的科学发展。